肌腱蛋白C在直肠癌及胃癌组织中的表达及临床意义 |
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引用本文: | 赵寅生,周昌莉,蔡春林,沙泉. 肌腱蛋白C在直肠癌及胃癌组织中的表达及临床意义[J]. 安徽医科大学学报, 2017, 52(10). DOI: 10.19405/j.cnki.issn1000-1492.2017.10.025 |
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作者姓名: | 赵寅生 周昌莉 蔡春林 沙泉 |
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作者单位: | 1. 安徽医科大学免疫学教研室及过敏与免疫研究中心,合肥,230032;2. 安徽医科大学病理与生理学教研室,合肥,230032 |
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基金项目: | 国家自然科学基金,安徽省自然科学基金 |
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摘 要: | 目的 研究肌腱蛋白C(TN-C)在直肠癌及胃癌组织中的表达及其临床意义.方法 采用免疫组织化学技术,分别对34例直肠癌及29例胃癌组织标本进行处理,分析TN-C在直肠癌及胃癌不同分化程度及临床分期中的表达强度.结果 34例直肠癌标本及29例胃癌标本均呈阳性表达;随着病理学分级的增高TN-C的表达逐渐增强,高分化与中分化、中分化与低分化癌变组织中TN-C表达相比,差异有统计学意义(P<0.05);随着临床分期的增加,TN-C的表达也逐渐增强,Ⅰ~Ⅱ期直肠癌和胃癌患者组织TN-C表达与Ⅲ~Ⅳ期患者相比较,差异有统计学意义(P<0.05).结论 在直肠癌及胃癌组织中均有TN-C的表达,且表达量与肿瘤分化程度及临床分期相关.
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关 键 词: | 肌腱蛋白C 直肠癌 胃癌 免疫组化 |
The expression and clinical significance of tenascin C in rectal cancer and gastric cancer |
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Abstract: | Objective To study the expression and clinical significance of tenascin C (TN-C) in rectal cancer and gastric cancer.Methods Immunohistochemistry technique was used to exam the expression of TN-C in 34 cases of rectal cancer and 29 cases of gastric cancer tissue.The correlation between TN-C expression and clinicopathologic stage in rectal cancer and gastric cancer was analyzed.Results All 34 cases of rectal cancer tissues and 29 cases of gastric cancer expressed TN-C.The expression of TN-C gradually increased with the pathological grading.There was statistically significance (P < 0.05) of TN-C expression in cancer tissues of high differentiation campared with moderate differentiation,and moderate differentiaton compared with low differentiation.The expression of TN-C in cancer tissues gradually enhanced with the clinical stage.There was statistically significance (P < 0.05) of TN-C expression in Ⅰ ~ Ⅱ rectal cancer and gastric cancer compared with that in Ⅲ ~ Ⅳ rectal and gastric cancer.Conclusion The expression of tenascin C in rectal cancer and gastric cancer is correlated with tumor differentiation and clinical stage. |
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Keywords: | tenascin C rectal cancer gastric cancer immunohistochemistry |
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