| FGF10对鸡胚尿囊膜血管形成的影响 |
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| 引用本文： | 刘芳,李刚,张丝雨,张小涵.FGF10对鸡胚尿囊膜血管形成的影响[J].安徽医科大学学报,2017,52(2). |
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| 作者姓名： | 刘芳 李刚 张丝雨 张小涵 |
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| 作者单位： | 南昌大学医学部基础医学院细胞生物学教研室,南昌,330031;南昌大学医学部基础医学院细胞生物学教研室,南昌,330031;南昌大学医学部基础医学院细胞生物学教研室,南昌,330031;南昌大学医学部基础医学院细胞生物学教研室,南昌,330031 |
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| 摘 要： | 目的 研究纤维母细胞生长因子FGF10对鸡胚尿囊膜血管生长作用,探讨FGF10对血管形成的影响.方法 应用胶原蛋白共培养方法,将FGF10(100 ng/ml)单独或与FGF受体拮抗剂SU5402(20μmol/L)作用于鸡胚尿囊膜血管内皮细胞组织块,观察FGF10对新生血管形成的影响.结果 与空白对照组比较,FGF10组新生血管形成面积显著增加(P<0.001).SU5402可抑制FGF10的作用,与空白对照组比较,其新生血管形成面积显著下降(P<0.001).结论 FGF10能促进鸡胚尿囊膜新生血管的形成.
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| 关 键 词： | FGF10 SU5402 血管形成 |
Influence of FGF10 on the angiogenesis of chorioallantoic membrane vessels |
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| Abstract: | Objective To study the effect of FGF10 on the angiogenesis of chicken chorioallantoic membrane ( CAM) vessels. Methods By using collagen co-culture method, FGF10 (100 ng/ml) alone or with its antagonist SU5402 (20 μmol/L) were acted on the endothelial vessel explants, and then the in vitro angiogenesis experiment was carried out. Results Compared with the control groups, FGF10 promoted the area of vessel outgrowth ( P<0. 001). However, SU5402 suppressed the effect of FGF10;compared with blank control groups, the area of new-born vessels decreased significantly ( P<0. 001 ) . Conclusion FGF10 has the function of enhancing the formation of new CAM vessels. |
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| Keywords: | FGF10 SU5402 angiogenesis |
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