高血压合并阻塞性睡眠呼吸暂停综合征患者的动脉硬化程度比较

目的 比较高血压病3级合并不同程度阻塞型睡眠呼吸暂停低通气综合征(OSAHS)患者的动脉粥样硬化及炎症水平.方法 选择2013年8月至2016年8月在安徽医科大学第三附属医院治疗的高血压3级患者169例,依据呼吸暂停低通气指数(AHI)分为对照组(无OSAHS)、轻度OSAHS组(AHI为5~14)、中度OSAHS组(AHI为15~30)和重度OSAHS组(AHI>30),比较分析患者总胆固醇、高密度脂蛋白和动脉粥样硬化指数(AI)、超敏C反应蛋白(hs-CRP)、颈动脉内中膜厚度(IMT)及踝肱指数(ABI).结果 4组患者的IMT、hs-CRP、AI及ABI差异有统计学意义(P<0.05),但对照组与轻度OSAHS组的IMT、hs-CRP、ABI及AI差异无统计学意义(P>0.05),而中度、重度OSAHS组的IMT、hs-CRP、AI较对照组明显升高,ABI明显下降,差异有统计学意义(P<0.05).结论 高血压病3级合并OSAHS,随着睡眠呼吸暂停低通气程度的加重,其动脉粥样硬化及炎症水平的指标明显升高.

Comparative study of atherosclerosis and inflammatory response in patients of hypertension with different levels of obstructive sleep apnea hypopea syndrome

Objective To investigate the level of the atherosclerosis and inflammatory response indicators in the patients of hypertension with different degrees of OSAHS. Methods The patients were collected from August 2013 to August 2016 in our hospital. Sleep apnea was monitored and the patients were randomly divided into four groups according to apnea hypopnea index (AHI), namely, control group, mild OSAHS group, moderate OSAHS group and severe OSAHS group. TC, HDL, AI, hs-CRP, IMT and ABIwere detected. The hs-CPR,IMT,ABI and AI were compared. Results There was no difference in IMT, hs-CRP,ABI and AI between the control group and mild OSAHS group (P>0.05). IMT, hs-CRP, and AI in the moderate group and severe OSAHS groupincreased significantly and ABI significantly decreased (P<0.05). Among all the groups,the severe OSAHS group was the most serious.Conclusion The patients of hypertension with OSAHS are severe in atherosclerosis and inflammation index, especially hypertension with severe AHI patients. So hypertension with OSAHSis markedly related to atherosclerosis and inflammation.