间苯三酚在预防下尿路微创手术术后膀胱痉挛中的应用

目的 观察间苯三酚预防下尿路微创手术术后膀胱痉挛的效果.方法 选取接受下尿路微创手术治疗的病人160例,依据随机数字表法分为观察组(间苯三酚预防+常规治疗)和对照组(常规治疗),每组80例,比较两组膀胱痉挛发作次数、持续时间、疼痛程度及不良反应发生情况.结果 观察组术后>0~≤24、>24~≤48、>48~≤72 h膀胱痉挛发作次数分别为(0.89±0.27)次、(1.92±0.65)次、(1.32±0.78)次;对照组术后相应时间内膀胱痉挛发作次数分别为(1.26±0.49)次、(2.53±0.42)次、(2.14±0.63)次,差异有统计学意义(P<0.05).观察组术后>0~≤24、>24~≤48、>48~≤72 h膀胱痉挛持续时间分别为(0.40±0.12)、(0.47±0.23)、(0.42±0.15) h;对照组术后相应时间内膀胱痉挛持续时间分别为(0.78±0.25)、(0.71±0.19)、(0.61±0.23) h,差异有统计学意义(P<0.05).观察组膀胱痉挛疼痛程度分别为轻度58例(72.50%),中度22例(27.50%),无重度疼痛病人;对照组膀胱痉挛疼痛程度分别为轻度17例(21.25%),中度45例(56.25%),重度18例(22.50%),差异有统计学意义(P<0.05).观察组口干4例(5.00%),头晕、头痛4例(5.00%),心悸2例(2.50%),视物模糊3例(3.75%),不良反应总发生率为16.25%;对照组口干10例(12.50%),头晕、头痛11例(13.75%),恶心4例(5.00%),心悸5例(6.25%),视物模糊3例(3.75%),不良反应总发生率为41.25%,差异有统计学意义(P<0.05).结论 间苯三酚的预防性使用能够明显降低下尿路微创手术病人术后膀胱痉挛发作次数及持续时间和缓解痉挛疼痛程度,值得临床推广.

Phloroglucinol minimally invasive surgery in the prevention of urinary tract bladder spasm after application

Objective To investigate the prevention effect of phloroglucinol on bladder spasm after minimally invasive lower urinary tract surgery.Methods 160 patients minimally invasive surgical treatment of lower urinary tract in our hospital were selected,which were divided into two groups (phloroglucinol preventive and routine treatment) and control group (conventional treatment) according to the random number table method.The bladder spasm episodes,duration,pain and adverse events of patients were compared.Results The bladder spasm episodes of observation group after >0~≤24,>24~≤48,>48~≤72 h were (0.89±0.27) times,(1.92±0.65) times,(1.32±0.78) times respectively,while in the control group were (1.26±0.49) times,(2.53±0.42) times,(2.14±0.63) times.The difference was statistically significant (P<0.05).The bladder spasm duration of observation group after >0~≤24,>24~≤48,>48~≤72 h was (0.40±0.12),(0.47±0.23),(0.42±0.15) h,while in the control group was (0.78±0.25),(0.71±0.19),(0.61±0.23) h.The difference was statistically significant (P<0.05).80 cases of the observation group,bladder spasm pain:mild 58 cases (72.50%) of mild pain and 22 cases (27.50%) moderate pain,no patients with severe pain.80 cases in the control group,bladder spasm pain:mild 17 cases (21.25%),moderate 45 cases (56.25%),severe 18 cases (22.50%).The difference was statistically significant (P<0.05).In the observation group 4 patients with dry mouth (5.00%),4 cases of dizziness and headache (5.00%),two cases of palpitation (2.50%),and three cases of blurred vision (3.75%).The overall incidence of adverse reactions was 16.25%.In the control group,10 cases of dry mouth (12.50%),11 cases of dizziness,headache(13.75%),4 cases of nausea (5.00%),5 cases of palpitations (6.25%),three cases of blurred vision and (3.75%) and the overall incidence of adverse reactions 41.25 %.The difference was statistically significant (P<0.05).Conclusions Pre-treated with phloroglucinol can significantly reduce the lower urinary tract bladder spasm episodes and duration,relieve spasm pain,prophylactic use of after minimally invasive surgery in patients,which worthy of promotion.