亚低温治疗对心脏骤停综合征病人血清S100b蛋白及格拉斯哥评分的影响

目的 观察亚低温(MHT)治疗对心脏骤停后综合征(PCAS)病人血清S100b蛋白浓度及格拉斯哥(GCS)评分的影响.方法 选取60例PCAS病人为研究对象,根据就诊时间不同分为观察组(30例)和对照组(30例),所有病人均采用针对性常规治疗方案,观察组于病人恢复自主循环(ROSC)后即刻加用MHT方案,分别于病人ROSC后T1(0 h)、T2(6 h)、T3(12 h)、T4(第1天)、T5(第3天)、T6(第7天)检测血清S100b蛋白浓度并于T1、T4、T5、T6时间点对病人进行GCS评分.结果 病人ROSC后T1时,S100b蛋白浓度组间差异无统计学意义(P>0.05),T2、T3、T4、T5、T6各时间点,观察组S100b蛋白浓度显著低于对照组(P<0.001);两组病人在T1、T4、T5 GCS评分差异无统计学意义(P>0.05),在T6时,观察组GCS评分明显高于对照组(P<0.05).结论 对于PCAS病人,MHT治疗可以降低病人血清S100b蛋白浓度,改善GCS评分,具有保护脑组织,减轻神经功能损伤的作用,且具有延迟效应.

Effect of mild hypothermia therapy on serum S100b protein and GCS score for patients with post-cardiac arrest syndrome

Objective To observe the influence of concentration of serum S100b protein and GCS of patients with post-cardiac arrest syndrome (PACS) treated with mild hypothermia (MHT) therapy.Methods According to the different time of treatment,60 cases of PCAS patients were divided into observation group (30 cases) and control group (30 cases).All patients received common treatment.The patients in observation group got restoration of spontaneous circulation (ROSC),MHT treatment was added immediately.After the ROSC,serum S100b protein of patients were detected at the time points of T1 (0 h),T2 (6 h),T3 (12 h),T4 (d1),T5 (d3),T6(d7) respectively and GCS was evaluated at the time points of T1,T4,T5,T6.Results After ROSC,at time point of T1,there were no significant differences between these two groups.At time points of T2,T3,T4,T5,T6,serum S100b protein of observation group was lower than control group,and the differences were statistically significant (P<0.001).For time points of T1,T4,T5,the differences of GCS between these two groups were not significant (P>0.05).However,at time point of T6,GCS of observation group was apparently higher than control group (P<0.05).Conclusions To the patient with PCAS,MHT therapy can decrease the level of serum S100b protein and improve GCS,which could protect brain tissue and reduce neurological function damage and also has delayed effect.