全脑放疗联合靶向治疗与同步放、化疗治疗非小细胞肺癌脑转移的临床疗效

目的 对比分析全脑放疗联合靶向治疗与同步放、化疗治疗非小细胞肺癌(NSCLC)脑转移的临床疗效及安全性.方法选取NSCLC脑转移病人56例作为研究的对象,经随机数字表法将之分为联合组与放化疗组,联合组病人采取全脑放疗联合靶向药物治疗,放化疗组采取全脑放疗以及同步化疗治疗.对病人进行为期2年的随访,比较两组病人治疗6个月后的临床疗效,并观察病人治疗期间并发症的发生情况以及随访期间的生存情况.结果联合组的脑转移病灶、总体评价的治疗有效率(RR)、疾病控制率(DCR)均显著高于放化疗组(P<0.05);联合组骨髓抑制、消化道反应的发生率均显著低于放化疗组,而皮疹脱屑的发病率则高于放化疗组(P<0.05);联合组1年生存率显著高于放化疗组,且平均生存时间较放化疗组更长(P<0.05);治疗结束后,联合组生存质量上升者显著多于放化疗组,而生存质量下降者则显著少于放化疗组(P<0.05).结论全脑放疗联合靶向治疗应用于NSCLC脑转移病人具有较好的疗效,能够减少不良反应,延长病人的生存时间.

Clinical effect of whole brain radiotherapy combined with targeted therapy and synchronous radiotherapy and chemotherapy in the treatment of non-small cell lung cancer with brain metastasis

Objective To compare the clinical efficacy and safety of whole brain radiotherapy combined with targeted therapy and syn-chronous radiotherapy and chemotherapy in the treatment of non-small cell lung cancer (NSCLC)with brain metastases.Methods Fifty six cases of NSCLC patients with brain metastasis were selected as the research object,and divided into combined group and chem-otherapy group according to the random number table method.The patients of the combination group were treated with whole brain radio-therapy combined with target to drug treatment,while radiotherapy and chemotherapy group were treated with whole brain radiotherapy and concurrent chemotherapy treatment.Patients were followed up for 2 years.The clinical efficacy of 2 groups of patients after 6 month-sof treatment were compared,and the incidence of complications during treatment and the survival of patients during follow up were ob-served.Results Brain metastasis lesions,the overall evaluation of the RR,DCR in combined group were significantly higher than that of the chemoradiotherapy group (P<0.05).The bone marrow suppression,gastrointestinal reaction incidence in combined group were significantly lower than those in the chemoradiotherapy group,and the rash with desquamation of the incidence was higher than chemo-therapy group (P<0.05).In combined group,1 year survival rate was significantly higher and the average survival time is longer than that in chemotherapy group (P<0.05).After the treatment,the survival quality of the combined group increased significantly than the chemotherapy group,and the rate of decreased quality of life is significantly reduced than chemoradiotherapy group (P<0.05 ).Con-clusion Whole brain radiotherapy combined with targeted therapy in patients with brain metastases of NSCLC has good therapeutic effect,which can reduce the adverse reaction and prolong the survival time of patients.