| 微小RNA-21评估结肠癌Ⅱ期患者预后价值的meta分析 |
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| 引用本文： | 郑强,余昌俊,康伟彪. 微小RNA-21评估结肠癌Ⅱ期患者预后价值的meta分析[J]. 安徽医学, 2017, 38(10): 1255-1258. DOI: 10.3969/j.issn.1000-0399.2017.10.007 |
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| 作者姓名： | 郑强 余昌俊 康伟彪 |
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| 作者单位： | 230032合肥,安徽医科大学第一附属医院胃肠外科三病区;230032合肥,安徽医科大学第一附属医院胃肠外科三病区;230032合肥,安徽医科大学第一附属医院胃肠外科三病区 |
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| 摘 要： | 目的 探究微小RNA-21能否成为预测结肠癌Ⅱ期患者预后的分子标志物,为临床决策提供参考.方法 在PubMed、Web of Science、EMBASE和CNKI电子数据库中检索关于微小RNA-21与结肠癌Ⅱ期患者预后关系的研究,采用ReviewManager 5.3和Stata 12.0软件进行meta分析.结果 共纳入8篇文献,包括1 533例结肠癌Ⅱ期患者.对于微小RNA-21与结肠癌Ⅱ期患者总生存期和无病生存期的研究中,采用固定效应模型计算合并风险比及95％置信区间分别为1.43(1.28～1.60)与2.76(1.71 ～4.47),且微小RNA-21高表达组与低表达组患者预后状态的差异均具有统计学意义(P＜0.05).结论 高表达微小RNA-21是结肠癌Ⅱ期患者的危险因素,作为评估结肠癌Ⅱ期患者预后分子标志物可能存在研究价值.
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| 关 键 词： | 结肠癌 微小RNA-21 预后 meta分析 |
| 收稿时间： | 2016-12-10 |
Prognostic value of miR-21 in stage II colon cancer: a meta-analysis |
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| ZHENG Qiang,YU Changjun and KANG Weibiao. Prognostic value of miR-21 in stage II colon cancer: a meta-analysis[J]. Anhui Medical Journal, 2017, 38(10): 1255-1258. DOI: 10.3969/j.issn.1000-0399.2017.10.007 |
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| Authors: | ZHENG Qiang YU Changjun KANG Weibiao |
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| Affiliation: | Department of Gastrointestinal Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China,Department of Gastrointestinal Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China and Department of Gastrointestinal Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China |
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| Abstract: | Objective To elucidate whether miR-21 as a molecular biomarker can predict the prognosis of patients with stage Ⅱ colon cancer or not.Methods wide range of databases (PubMed,Web of Science,EMBASE and CNKI) for miR-21 expression associated with prognosis of stage Ⅱ colon cancer patientswere searched.Review Manager 5.3 and Stata12.0 were used to calculate the pooled effect values.Results Eight studies including a total of 1533 patients with stage Ⅱ colon cancer were enrolled.The pooled hazard ratio value of disease free survival and overall survival correlated with miR-21expression in stage Ⅱ colon cancer patients were 1.43 (1.28-1.60) and 2.76(1.71-4.47),respectively.Moreover,the difference between high expression group and low related to prognosis of patients was statistically significant (P ＜ 0.05)..Conclusion Highly expressed miR-21 is an independent risk factorof colon cancer,which may serve as a promising prognostic molecular biomarker in stage Ⅱ colon cancer. |
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| Keywords: | Colon cancer miR-21 Prognosis Meta-analysis |
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