红细胞分布宽度、C-反应蛋白及肺泡表面活性蛋白-D水平对慢性阻塞性肺疾病病情变化的意义

目的 探讨红细胞分布宽度、C-反应蛋白(CRP)及肺泡表面活性蛋白-D水平在慢性阻塞性肺疾病(COPD)的变化及其意义.方法 选取COPD急性期病人60例,纳入COPD急性期组;选取同期COPD稳定期病人60例,纳入COPD稳定期组;另选健康人员60例,纳入健康对照组.比较三组红细胞分布宽度、CRP、白细胞计数、肺泡表面活性蛋白-D水平及COPD病人肺功能情况.结果 与健康对照组相比,COPD急性期组与COPD稳定期组病人红细胞分布宽度、白细胞计数、肺泡表面活性蛋白-D水平较高(P<0.05);与COPD稳定期组相比,COPD急性期组病人血清CRP、肺泡表面活性蛋白-D水平较高(P<0.05).与COPD稳定期组相比,COPD急性期组病人第1秒用力呼气容积与用力肺活量比值较低(P<0.001).结论 红细胞分布宽度、CRP及肺泡表面活性蛋白-D水平可用于评价慢性阻塞性肺疾病病人的病情变化,值得临床推广.

Change and its significance of red cell distribution width,C-reactive protein level and pulmonary surfactant protein-Din chronic obstructive pulmonary disease

Objective To explore the change and significance of red cell distribution width,C-reactive protein level and pulmonary surfactant protein-D in chronic obstructive pulmonary disease (COPD).Methods Sixty patients with COPD acute period were assigned into COPD acute period group.Another 60 patients with COPD stable period after treatment and 60 healthy persons having health examination in the same hospital over the same period were assigned into COPD stable period group and healthy control group,respectively.The levels of red cell distribution width,C-reactive protein,white blood cell counts,pulmonary surfactant protein-D and pulmonary functionwere compared among three groups.Results Compared to healthy control group,patients in the COPD acute period group and COPD stable period group had higher levels of red cell distribution width,white blood cell counts and pulmonary surfactant protein-D (P<0.05).Compared to COPD stable period group,patients in the COPD acute period group had higher levels of C-reactive protein and pulmonary surfactant protein-D (P<0.05).Compared to COPD stable period group,patients in the COPD acute period group had lower FEV1/FVC (P<0.001).Conclusions Red cell distribution width,C-reactive protein level and pulmonary surfactant protein-D can be used for the evaluation of patients with chronic obstructive pulmonary disease and it is worthy of clinical promotion.