氯气对鼻灌洗液某些炎症标志物水平的影响

目的 探讨氯气损害呼吸道的机制。方法 应用鼻灌洗(Nasal lavage，NAL)方法，研究17名造纸工人接触氯气前后鼻灌洗液中几种炎症标志物的浓度变化。结果 吸入氯气4周后，鼻灌洗液中尿素、尿酸、白细胞介素．8浓度明显升高，白蛋白浓度无显著性改变，白细胞介素．6未检出。结论 氯气接触可引起鼻粘膜通透性改变以及鼻粘膜上皮细胞的炎症反应。鼻灌洗操作方法简便、安全，是研究呼吸道病理生理变化的一种有效方法。

Effects of chlorine exposure on infiammatory markers in nasal lavage fluid

Objective To study the mechanism of the damages in respiratory tract caused by chlorine exposure.Methods The concentrations of several inflammatory markers in nasal lavage fluid(NLF)were determined before and after chlorine exposure in 17 papermaking workers in a pulp mill.Results Concentrations of urea,uric acid and interleukin 8 in NLF increased significantly four weeks after chlorine inhalation,no significant change in albumin level of NLF was observed and no interleukin 6 was detected in NLF.Conclusions Chlorine exposure can cause the changes in permeability of nasal mucous membrane and inflammatory reaction of mucous epithelial cells.Nasal lavage is a simple and safe method to study the pathophysiological changes in respiratory tract.