Treatment of negative and cognitive symptoms |
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Authors: | Daniel C Javitt MD PhD |
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Institution: | (1) Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, 10962 Orangeburg, NY, USA |
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Abstract: | Persistent negative symptoms and cognitive dysfunction are a major cause of chronic disability in schizophrenia. Atypical
antipsychotics such as clozapine, risperidone, and olanzapine induce significantly greater improvement in negative symptoms
than that which is obtained with conventional agents. However, it remains unclear whether these agents treat core negative
symptoms of schizophrenia, or simply induce less secondary psychopathology. A second approach for treatment of persistent
negative symptoms is the use of N-methyl-D-aspartate (NMDA) receptor-stimulating agents, such as glycine, D-serine or D-cycloserine.
These agents, when added to conventional or atypical antipsychotics, may induce significant additional reduction in both negative
and cognitive symptoms. |
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Keywords: | |
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