| 肝硬化鼠肝缺血再灌注胃粘膜病理损伤的研究 |
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| 引用本文： | 褚延魁,马庆久,刘维,王胜智,辛洁. 肝硬化鼠肝缺血再灌注胃粘膜病理损伤的研究[J]. 肝胆外科杂志, 2003, 11(1): 70-71 |
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| 作者姓名： | 褚延魁 马庆久 刘维 王胜智 辛洁 |
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| 作者单位： | 1. 第四军医大学唐都医院普外科,西安,710038
2. 第四军医大学西京医院供应室 |
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| 摘 要： | 目的 探讨肝缺血再灌注对肝硬化鼠胃粘膜的病理损伤过程。方法：实验大鼠制备肝硬化模型。并行肝脏缺血再灌注，取大鼠胃粘膜标本行电镜，光镜检查。并检测血中转氨酶的变化。结果 肝硬化鼠胃粘膜出现充血，水肿，有糜烂及小溃疡形成，电镜见内质网扩张，线粒体肿胀。肝缺血再灌注后病理过程较前加重，表现为溃疡面的扩大，部分出现粘膜上皮脱落等。细胞崩解。内质网扩张明显。核膜不清。结论 肝缺血再灌注加重了门脉高压性胃炎的病理过程。
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| 关 键 词： | 肝硬化 肝缺血再灌注 胃粘膜 损伤 |
| 文章编号： | 1006-4761(2003)01-0070-02 |
| 修稿时间： | 2002-09-17 |
PATHOMORPHOLOGICAL CHANGE IN GASTRIC MUCOSA AFTER LIVER ISCHEMIA REPERFUSION IN CIRRHOTIC RATS |
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| Chu Yankui,Ma Qingjiu,Liu Wei,Wang Shenzhi. PATHOMORPHOLOGICAL CHANGE IN GASTRIC MUCOSA AFTER LIVER ISCHEMIA REPERFUSION IN CIRRHOTIC RATS[J]. Journal of Hepatobiliary Surgery, 2003, 11(1): 70-71 |
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| Authors: | Chu Yankui Ma Qingjiu Liu Wei Wang Shenzhi |
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| Affiliation: | Chu Yankui,Ma Qingjiu,Liu Wei,Wang Shenzhi.Department of Surgery,Tang Du Hospital,Fourth military medical university,Xi'an 710038 China |
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| Abstract: | Objective To study the pathomorphological change in gastric mucosa after liver ischemia reperfusion in cirrhotic rats.Methods 140 liver cirrhosis rats was prepared.Ischemia reperfusion was performed in each group.Pathological change was studied by light and transmission electronic microscopy.Blood ALT AST was detected.Results Gastric mucosa show edema congestion in cirrhotic rats,erosion and small ulcers was also observed.Morphology on transmission electronic microscopc manifested dilatation of SER and mitochondrion,pathological procedure aggravated after IR.Conclusion Pathomorphological procedure in PHG rats was aggravated after IR. |
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| Keywords: | Liver cirrhosis Ischemia reperfusion Gastric mucosa injury |
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