Senile plaques in very aged cats |
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Authors: | Shin-ichiro Nakamura H. Nakayama Wijit Kiatipattanasakul Koji Uetsuka Kazuyuki Uchida Naoaki Goto |
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Affiliation: | (1) Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113, Japan, JP;(2) Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, 1–1 Gakuen-Kihanadai Nishi, Miyazaki 889–21, Japan, JP |
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Abstract: | Senile plaques were found in the cerebral cortices of three very aged cats (more than 18 years old). The plaques consisted of a coarse assembly of silver staining-positive materials, and was morphologically different from the well-known classical, primitive, and diffuse plaques. Congophilic amyloid angiopathy was observed in a few cortical arterioles of the oldest cat (20 years old). The senile plaques and a few cortical blood vessels were immunopositive for amyloid β-protein (Aβ). Aβ-positive materials were also sparsely distributed in the cortical neuropil but did not form senile plaques there. These findings should help to clarify the development of senile plaques and the early stage of Aβ deposition. Received: 29 May 1995 / Revised, accepted: 28 September 1995 |
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Keywords: | Amyloid β -protein Cat Senile plaque |
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