Mutagenic evaluation of the pesticides captan, folpet, captafol, dichlofluanid and related compounds with the mutants TA102 and TA104 of Salmonella typhimurium

A mutagenic evaluation of captan, folpet, captafol, dichlofluanidand related compounds was carried out using the Salmonella/mammalianmicrosome test using strains TA102 and TA104. These strainscontain A-T base pairs at the site of the mutation in contrastto the other Salmonella tester strains that detect mutagensdamaging G-C base pairs. In addition, the excision repair systemof the TA102 strain is still intact. Captan and folpet weremutagenic in strain TA104, captafol was mutagenic in strainTA102, whereas the remaining test compounds (dichlofluanid,tetrahydro-phthalimide and thiozolidine-4-carboxylic acid) werenot mutagenic in either strain. In conclusion, we consider itof value to add these two strains to those already used in theAmes test in order to increase confidence in our ability todetect mutagens and to shed further light on their mechanismof action.