| 石杉碱甲对急性水胺硫磷和辛硫磷中毒时AChE活力的影响 |
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| 引用本文： | 刘黎,谢广云,王健,赵文锦,孙金秀. 石杉碱甲对急性水胺硫磷和辛硫磷中毒时AChE活力的影响[J]. 中国工业医学杂志, 2011, 24(2): 92-94 |
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| 作者姓名： | 刘黎 谢广云 王健 赵文锦 孙金秀 |
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| 作者单位： | 中国疾病预防控制中心职业卫生与中毒控制所; |
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| 摘 要： | 目的观察石杉碱甲(哈伯因,HupA)对水胺硫磷和辛硫磷急性染毒小鼠的AChE活力的影响。方法实验小鼠随机分为HupA干预组和未干预组,所有小鼠均经口给予一定剂量水胺硫磷或辛硫磷,干预组小鼠于染毒前2 h经口给予HupA,而后定时测定染毒后全血、红细胞和脑组织的AChE活力值。结果无论是水胺硫磷还是辛硫磷染毒,HupA干预组的全血、红细胞及脑组织AChE活力均高于同时点的未干预组。结论 HupA可以对抗水胺硫磷和辛硫磷对AChE活性的抑制作用,提示HupA可能具有预防和治疗水胺硫磷和辛硫磷中毒的作用。
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| 关 键 词： | 石杉碱甲(哈伯因) AChE 水胺硫磷 辛硫磷 |
Effect of Huperzine A on AChE activity in blood of rats during acute isocarbophos or phoxim poisoning in mice |
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| LIU,Li,XIE Guang-yun,WANG Jian,ZHAO Wen-jin,SUN Jin-xiu. Effect of Huperzine A on AChE activity in blood of rats during acute isocarbophos or phoxim poisoning in mice[J]. Chinese Journal of Industrial Medicine, 2011, 24(2): 92-94 |
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| Authors: | LIU Li XIE Guang-yun WANG Jian ZHAO Wen-jin SUN Jin-xiu |
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| Affiliation: | LIU,Li,XIE Guang-yun,WANG Jian,ZHAO Wen-jin,SUN Jin-xiu(National Institute of Occupational Health and Poison Control,Chinese Center for Disease Control and Prevention,Beijing 100050,China) |
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| Abstract: | Objective To research the effect of Huperzine A(HupA)on blood AChE during acute isocarbophos or phoxim poisoning in mice.Methods The mice were randomly divided into HupA-treated groups and non-treated groups.All the mice were orally administrated with isocarbophos or phoxim,HupA was administrated by gavage 2 h before pesticides exposure,and then,the AChE activity in blood,red blood cell and brain tissue were periodically detected.Results All the AChE activities in whole blood,red blood cell and brain tissue... |
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| Keywords: | Huperzine A(HupA) acetylcholinesterase(AChE) isocarbophos phoxim |
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