富嘌呤食物摄入及肥胖、饮酒等因素与高尿酸血症的相关性

目的调查北京地区部分人群中高尿酸血症的流行状况,分析各种富嘌呤食物、肥胖和饮酒等因素对其的影响。方法对2005年9～12月在我院参加年度体检的国家机关和事业单位人群进行横断面调查,了解该人群中高尿酸血症的流行状况。采用食物频度法调查各种富嘌呤食物和高蛋白食品摄入。通过Logistic多元回归模型分析高尿酸血症与营养摄入相关因素的关联。结果高尿酸血症的发生率为10.9%,其中男性为13.8%,女性为6.3%。双变量分析和Logistic多元回归分析显示,男性、饮酒次数、每周饮白酒≥7个单位酒精饮品、超重/肥胖、腹型肥胖、高血糖、高胆固醇血症、高甘油三脂血症与高尿酸血症的危险性升高相关(P<0.05)。经常食用肉汤、海鲜类食物、内脏、箘类等富含嘌呤的食物在男性和女性中均与高尿酸血症的发生无明显相关性。食用坚果、经常在饭店进餐、肉汤类食物与女性超重/肥胖的发生密切相关(P<0.05),但与其高尿酸血症的危险性升高无明显相关。结论男性、饮用白酒、腹部肥胖、高甘油三酯血症、高胆固醇血症可能与高尿酸血症发生的危险性升高相关,而富嘌呤食物摄入与其未见显著相关。

Epidemiological Relativity Study of Hyperuricemia with Factors of Purine-rich Food, Obesity, and Drinking

Objective To investigate the prevalence of hyperuricemia and its associated factors including purine-rich food,obesity, and drinking in some population in Beijing. Methods A cross-sectional study of hyperuricemia was carried out in state-employees who had yearly health examination at our hospital in Beijing from September to December 2005. The prevalence of hyperuricemia was calculated in the population. The form of food frequency was used to understand the intake status of purine-rich food. Data were further analyzed by multivariate logistic regression models to identify the risk factors of hyperuricemia. Results The prevalence of hyperuricemia in the population was 10.9%, and was 13.8% and 6.3% in men and women, respectively. Bivariate and multivariate logistic regression analysis showed that male gender, hard liquor, overweight/obesity, waist obesity, hypercholesterolemia, and hypertriglyceride were associated with increased prevalence of hyperuricemia (P<0.05) ; however, products of nutrient buillon, seafood, animal organs, and mushroom had no significant association with the prevalence of hyperuricemia in either men or women. The products of nuts, nutrient buillon, and eating in restaurant were significantly associated with the prevalence of overweight and obesity in women(P<0.05), was no significantly associated with the prevalence of hyperuricemia. Conclusions Male gender, hard liquor, waist obesity, hypercholesterolemia, and hypertriglyceride may increase the prevalence of hyperuricemia in some populations in Beijing. The purine-rich food may not be a risk factor of hyperuricemia.