Ketamine-induced rotational asymmetry in evaluation of motor disturbances in rats with middle cerebral artery occlusion |
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Authors: | Lebedev S V Petrov S V Blinov D V Lazarenko I P Chekhonin V P |
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Affiliation: | (1) V. P. Serbskii State Research Center for Social and Forensic Psychiatry, Moscow |
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Abstract: | Intraperitoneal injection of ketamine in subanesthetic doses to Wistar rats with unilateral occlusion of the middle cerebral artery caused ipsilateral rotation (2-10 rpm), which was recorded in an automatic rotameter. The optimal dose of ketamine was 50 mg/kg. The animals were examined in an automatic rotameter for 40 min. Motor asymmetry persisted for no less than 2 months after surgery. According to the neurological test (Menzies scale) motor asymmetry in animals with focal brain ischemia persisted for no more than 30 days. The degree of ketamine-induced motor asymmetry in intact rats was 0.10±0.03 rpm. |
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Keywords: | ketamine middle cerebral artery occlusion motor asymmetry automatic rotameter |
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