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Ncx, a Hox11 related gene, is expressed in a variety of tissues derived from neural crest cells |
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| Authors: | Masahiko Hatano Yoshinori Iitsuka Hiroyuki Yamamoto Mari Dezawa Seiichi Yusa Yoichi Kohno T. Tokuhisa |
| Affiliation: | Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, 1-8-1 Inohana, Chuoku, Chiba 260, Japan Tel.: 81-43-226-2181; Fax: 81-43-226-2183; e-mail:tokuhisa@med.m.chiba-u,ac.jp, JP Department of Ophthalmology, Kobe University School of Medicine, Kobe 650, Japan, JP Department of Anatomy, Chiba University of School of Medicine, Chiba 260, Japan, JP Department of Pediatrics, Chiba University School of Medicine, Chiba 260, Japan, JP |
| Abstract: | We have isolated the murine homeobox gene (Ncx) that belong to a Hox11 gene family. Expression of the Ncx gene was analyzed in total RNAs from embryos by reverse transcribed polymerase chain reaction (RT-PCR). The mRNA was detected in embryos after 9.5 days of embryogenesis (E9.5) and was maximal at E12.5. The RT-PCR also detected the message in total RNAs from adrenal glands and intestine in adult mice. The expression was further examined in various tissues from embryos by in situ hybridization. It was detected in dorsal root ganglia, cranial nerve ganglia (V, IX, X), enteric nerve ganglia and adrenal glands from embryos between E9.5 and E13.5. Since its expression is restricted to tissues derived from neural crest cells, Ncx may play a role in differentiation and proliferation of neural crest lineage cells. |
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