淋巴结转移阴性结直肠癌的临床病理特点及预后多因素分析

目的探讨淋巴结转移阴性结直肠癌的临床病理特点及其预后因素,为临床治疗提供依据.方法以我院1996至1999年间施行结直肠癌根治手术,检取5个以上淋巴结均无转移的247例患者为研究对象,总结临床病理特点;采用Kaplan-Meier法进行单因素分析,COX比例风险模型进行多因素分析,判定淋巴结转移阴性结直肠癌的独立预后因素.结果淋巴结转移阴性结直肠癌浸润深度较浅,肿瘤小,血清CEA值低.5年生存率为73.8%(175/237).结论淋巴结转移阴性结直肠癌施行根治术后预后较好,浸润深度和术前血清CEA值是其独立预后因素.

Clinicopathological characteristics and multivariate analysis of prognosis of colorectal cancer without lymph node metastasis

Objective To investigate the clinicopathological characteristics and assess the prognosis of colorectal cancer without lymph node metastasis in order to provide some useful information for therapy.Methods The clinicopathological characteristics of 237 cases of node-negative colorectal cancer, who received radical resection,were analyzed.At least 5 nodes were obtained per specimen.The Kaplan-Meier procedure and COX analysis were used to assess the prognosis.Results Invasive depth,size and preoperative level of carcinoembryonic antigen(CEA) in node-negative colorectal patients were significantly lower than those in the node-positives.The 5-year survival rate of the former was 73.8%.Invasive depth and preoperative level of CEA were two independent prognostic factors.Conclusion Patients with node-negative colorectal cancer may have good prognosis.Invasive depth and preoperative level of CEA can be used to predict outcome in node-negative colorectal cancer patients.