铝致Alzheimer病对尿中微量元素排出的影响

目的：探讨Alzheimer病时，对微量元素铜、锌、锰、硒、镉等在尿中排出的影响。方法：雌性健康SD大鼠29只，随机分为卵巢假切组（sham组）、卵巢切除组（ovx组）、卵巢切除合并慢性铝中毒组（ovx＋AL^3＋组）、卵巢切除合并慢性铝中毒及尼尔雌醇灌胃组（ovx＋＋AL^3＋＋E2组）。收集24的尿液，采用日本岛津ICPQ—1012型电感耦合等离子体发射光谱仪（ICP—AES）测定尿中微量元素含量。结果：卵巢切除合并慢性铝中毒及尼尔雌醇灌胃组（ovx＋＋AL^3＋＋E2组）分别与卵巢假切组比较尿铝（P〈0．01）、尿镁（P〈0．05）、尿硒（P〈0．01）、尿钙（P〈0．01）、尿镉（P〈0．05）排出明显增加；铜、锌、锰排出量与卵巢假切组相比均无统计学意义（P〉0．05）。结论：铝致Alzheimer病对尿中铝、镁、硒、钙和镉的排出明显增加，而对铜、锌、锰在尿中的排出无影响。

Effect of Alzheimer disease on urinary trace elements excretion in rats

Objective:To reveal the influence of Alzheimer disease on the urinary trace elements,Copper(Cu),Zinc(Zn),Manganese(Mn),selenium(Se)and cadmium(Cd) in rats.Methods:29 female SD rats were randomly divided into 4groups : sham group,ovx group,ovx+AL3+group and ovx++AL3++E2 group.The urine were collected and the trace elements contents were analyzed by ICP-AES.Results: ovx++AL3++E2 could highly increase aluminum,selenium,Zinc,cadmium,output,whereas the excretion of urinary Cu,Zn,Mn contents in the groups administered with sham was not significantly different comparing with that in control group.Conclusions: Alzheimer disease effectively enhance the elimination of AL,Mg,Se,Ca and exert little effect on urinary Cu,Zn,Mn excretion.