湿润烧伤膏在烧伤创面治疗中的作用

烧伤治疗一直是烧伤领域中的一大难题。烧伤创面的局部治疗要求早期清创，并为创面提供一个适宜的环境刺激上皮形成和细胞的分化。早在30年前，烧伤的标准化治疗方案就已经形成，包括早期切痂及韧厚皮移植，但治疗效果不尽人意。为了改善愈合后的皮肤质量，尤其是减少增生性瘢痕的产生，人们仍需探索新的治疗方法。笔者对Kilpauk医学院医院的烧伤患者进行了创面愈合评价，包括100名经湿润烧伤膏（MEBO）治疗的患者及100名经磺胺嘧啶银软膏治疗的患者，并对比分析了两组患者创面的愈合效果。结果显示，MEBO在深Ⅱ度浅型及深Ⅱ度深型烧伤患者的治疗中取得了成功。MEBO可在创面形成一种具有抗炎作用的生理性湿润环境。并为创面提供了一种营养基质，这种营养基质能清除创面焦痂并促进创面上皮再生。本前瞻性研究旨在评价MEBO在Ⅱ度烧伤中的应用效果。2010年8月至2011年5月期间，100名经MEBO治疗的Ⅱ度烧伤患者同另100名使用磺胺嘧啶银软膏治疗的Ⅱ度烧伤患者在清创效果，抗炎效果，愈合效果，瘢痕形成及色素沉着方面进行了对比。结果发现经过MEBO治愈的创面，皮肤颜色及瘢痕形成均优于磺胺嘧啶银组。

Moist Exposed Burn Ointment in the Management of Burn Wound

Management of burns remains one of the greatest challenges in burn care. Local management of a burn wound requires early wound debridement and an optimmn environment to stimulate epithelialisation and cellular prolifera- tion. Protocol was developed as early as 30 years ago for the management of burns that includes early excision and SSG cov- erage. The results were not perfect. The quality of healed skin as well as the prominence of hypertrophic scar needs to ex- plore the novel approaches. Wound healing assessment was made in burn wounds in 100 patients treated with MEBO cream and in 100 patients with Silver Sulpha Diazine Cream at the Kilpauk Medical College Hospital, Burns Unit. The comparative analysis is presented to assess the wound healing pattern in both the groups. Moist exposed burn ointment has been used with success in the management of deep superficial partial thickness and deep partial thickness burns in our department. The MEBO cream creates a physiological moist environment over the wound inducing an antiqnflammatory effect. It provides a nutritive base for the wound and debrides the wound eschar and expedites wound epithelialisation. The purpose of this study was to prospectively evaluate the outcome of the use of MEBO for second degree burns. Between August 2010 to May 2011 period 100 patients with second degree burns underwent MEBO cream application and were compared with 100 patients who had silver sulphadiazine cream . The result was analysed for the nature of wound debridement, reduction of inflammation, healing pattern, scar and pigmentation, MEBO provides excellent skin pigmentation and minimal visible scar.