Chemical delivery systems and soft drugs: Retrometabolic approaches of drug design |
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Authors: | Yashumati Ratan Bhardwaj Ashutosh Pareek Vivek Jain Dharma Kishore |
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Affiliation: | aDepartment of Pharmacy, Banasthali University, Banasthali-304022, Rajasthan, India;bDepartment of Chemistry, Banasthali University, Banasthali-304022, Rajasthan, India |
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Abstract: | Inclusion of metabolic considerations in the drug design process leads to significant development in the field of chemical drug targeting and the design of safer drugs during past few years which is a part of an approach now designated as Retro metabolic drug design (RMDD). This approach represents systematic methodologies that integrate structure–activity and structure–metabolism relationships and are aimed to design safe, locally active compounds with an improved therapeutic index. It embraces two distinct methods, chemical delivery systems and a soft drug approach. Present review recapitulates an impression of RMDD giving reflections on the chemical delivery system and the soft drug approach and provides a variety of examples to embody its concepts. Successful application of such design principles has already been applied to a number of marketed drugs like esmolol; loteprednol etc., and many other candidates like beta blockers, ACE inhibitors, alkylating agents, antimicrobials etc., are also under investigation. |
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Keywords: | Absorption Distribution Metabolism Excretion Retrometabolic drug design Chemical delivery system Soft drugs Soft drug design Angiotensin converting enzyme |
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