Syndrome de Sweet médicamenteux à l’hydroxychloroquine : à propos de 2 cas |
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| Institution: | 1. Service de médecine interne, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France;2. Service de dermatologie, groupe hospitalier du Havre, 29, avenue Pierre-Mendès, 76290 Montivilliers, France;3. Service d’anatomie pathologique, groupe hospitalier du Havre, 29, avenue Pierre-Mendès, 76290 Montivilliers, France;4. Service de rhumatologie, groupe hospitalier du Havre, 29, avenue Pierre-Mendès, 76290 Montivilliers, France;1. Service de pneumologie, hôpital François Mitterrand, 4, boulevard Hauterive, 64000 Pau, France;2. Service d’anatomopathologie, hôpital François-Mitterrand, 64000 Pau, France;3. Hôpital Rangueil-Larrey, Toulouse, France;4. Université Paul-Sabatier, Toulouse, France;1. Service de médecine interne, université Claude-Bernard Lyon 1, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, grande rue de la Croix-Rousse, 69004 Lyon, France;2. RADICO - AcoSTILL, Paris, France;3. Service de médecine interne, hôpital Tenon, AP–HP, 75000 Paris, France;4. Service de néphrologie, rhumatologie, dermatologie pédiatriques, université Claude-Bernard Lyon 1, hôpital Femme-Mère-Enfant, hospices civils de Lyon, 69500 Bron, France;5. Service de rhumatologie, hôpital Pitié-Salpêtrière, AP–HP, Paris, France;1. Service de dermatologie, CHU de Bordeaux, hôpital Saint-André, rue Jean-Burguet, 33000 Bordeaux, France;2. Service de radiothérapie, CHU de Bordeaux, hôpital Haut Lévêque, 33600 Pessac, France |
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| Abstract: | IntroductionHydroxychloroquine is widely prescribed in systemic lupus erythematosus. Dermatologic adverse drug reactions are rare but can mimic a disease specific manifestation of lupus. Exceptionally, Sweet's syndrome, or acute febrile neutrophilic dermatosis, may be drug-induced.Case reportsTwo patients aged 31 and 42 years were treated with hydroxychloroquine for systemic lupus and Sjogren's syndrome, respectively. Three weeks after starting treatment, they had a febrile, purple and erythematous papular rash of the trunk and limbs. There was a biological inflammatory syndrome and skin biopsy disclosed an infiltrate of the dermis rich in neutrophils. Lesions regressed after stopping hydroxychloroquine and introducing systemic corticosteroid therapy. Allergologic tests discussed the differential diagnosis with a delayed-type hypersensitivity reaction.ConclusionWe report two exceptional cases of drug-induced Sweet's syndrome related to hydroxychloroquine treatment in autoimmune rheumatic diseases. |
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| Keywords: | Sweet's syndrome Drug-induced dermatitis Hydroxychloroquine |
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