Genetic diversity of HLA system in two populations from Campeche,Mexico: Campeche city and rural Campeche |
| |
| Affiliation: | 1. Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany;2. Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico;3. Chemistry Faculty, Universidad Autónoma de Yucatán (UADY), Mérida, Yucatán, Mexico;4. Institute of Clinical Molecular Biology (IKMB), Kiel University, University Hospital, Schleswig-Holstein, Germany;5. Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany;6. Department of Molecular Biology, Laboratorios Diagnóstica, Villahermosa, Tabasco, Mexico;7. Blood Bank, UMAE Hospital de Gineco Obstetricia No. 4 “Luis Castelazo Ayala”, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico;8. Immunogenetics Unit, Técnicas Genéticas Aplicadas a la Clínica (TGAC), Mexico City, Mexico;9. Molecular Biology and Histocompatibility Laboratory, Hospital Central Sur de Alta Especialidad, Petróleos Mexicanos (PEMEX), Mexico City, Mexico;10. Unit of Research and Education in Health, Unidad Médica de Alta Especialidad (UMAE) # 10, Instituto Mexicano del Seguro Social (IMSS), Mérida, Yucatán, Mexico;11. Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico;12. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico;13. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA;14. Immunology and Infectology Research Unit, Infectology Hospital, Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico;15. Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán” (INCMNSZ), Mexico City, Mexico |
| |
| Abstract: | We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 81 Mexicans from the state of Campeche living in the city of Campeche (N = 34) and rural communities (N = 47), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Campeche include ten Native American, three European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Campeche are Native American (65.56 ± 0.96% by ML; 51.24% of Native American haplotypes), European (34.44 ± 10.94% by ML; 30.25% of European haplotypes), and a virtually absent African genetic component (0.00 ± 10.31% by ML; 9.26% of African haplotypes). |
| |
| Keywords: | HLA Immunogenetics Population genetics Campeche Admixture |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
