计算机断层扫描联合血清三叶因子1、微RNA-130a-5p检测对肺癌的诊断价值分析

目的 探究计算机断层扫描(CT)联合血清三叶因子1(TFF1)、微RNA-130a-5p(miR-130a-5p)检测对肺癌的诊断价值。方法 选取2015年2月至2016年9月石家庄市人民医院收治的94例肺癌病人为肺癌组，85例同期确诊的肺良性病变病人为良性病变组。对所有受试者进行CT检查，并分析CT对肺癌病人的诊断效能；采用酶联免疫吸附法(ELISA)检测血清TFF1水平；采用实时荧光定量PCR(qRT-PCR)检测血清miR-130a-5p相对表达量；ROC曲线分析血清TFF1、miR-130a-5p对肺癌的诊断价值；分析CT、TFF1、miR-130a-5p单独检测及联合检测对肺癌的诊断价值。结果 CT诊断肺癌误诊16例，19例漏诊。CT诊断肺癌的灵敏度为79.79%，特异度为81.18%，准确度为80.45%，误诊率、漏诊率分别为18.82%与20.21%。与良性病变组相比，肺癌组病人血清TFF1显著上升，miR-130a-5p水平显著下降(P<0.05)。血清TFF1、miR-130a-5p对肺癌诊断价值的曲线下面积(AUC)分别为0.85、0.83，截断值分别为1.1...

The diagnostic value of CT combined with serum TFF1 and miR-130a-5p detection in lung cancer

Objective To explore the value of computed tomography (CT) combined with serum trefoil factor 1 (TFF1) and miR-130a-5p in the diagnosis of lung cancer.Methods A total of 94 lung cancer patients admitted to Shijiazhuang People''s Hospital fromFebruary 2015 to September 2016 were selected as the lung cancer group, another 85 patients with benign lung lesions were selected asthe benign lesion group. CT examinations were performed on all subjects and the diagnostic efficacy of CT for lung cancer patients wasanalyzed. Enzyme-linked immunosorbent assay (ELISA) was used to check the level of serum TFF1 in patients, and real-time fluores-cence quantification PCR (qRT-PCR) was used to detect the relative expression level of serum miR-130a-5p in patients. ROC curve