High-resolution allele frequencies for NGS based HLA-A,B, C,DQB1 and DRB1 typing of 23,595 bone marrow donors recruited for the Polish central potential unrelated bone marrow donor registry |
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| Institution: | 1. Central Unrelated Potential Bone Marrow Donor And Cord Blood Registry Poltransplant, 87 Al. Jerozolimskie Str, 02-005 Warszawa, Poland;2. Regional Centre of Blood Donation and Blood Treatment in Poznan, 44 Marcelińska Str., 60-354 Poznań, Poland;3. Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, 251 Pomorska Str., Lodz, Poland;4. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 5a Pawinskiego Str., 02-106 Warsaw, Poland;5. Department of Emergency Medicine, Medical University of Warsaw, 61 Żwirki i Wigury Str., 02-091 Warsaw, Poland;6. Department of Immunogenetics, Institute of Hematology and Transfusion Medicine, 14 Indira Gandhi Street, 02-776 Warsaw, Poland;7. Department of Biochemistry and Microbiology, Warsaw University of Life Sciences, 159 Nowoursynowska Str., 02-776 Warsaw, Poland |
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| Abstract: | Next-generation sequencing (NGS)-based typings of HLA-A, B, C, DQB1 and DRB1 loci were performed from 2018 to 2019 in 23 595 newly recruited or re-typed adult potential bone marrow donors registered in Poltransplant Registry to characterize allele and haplotype frequencies of HLA system for loci important for hematopoietic stem cell transplantation. The donors were recruited for registry and not for any other purpose including controls in a disease association study. The population sample was collected in various regions of Poland including all voivodships. The data regarding the degree of relatedness among individuals in the sample were not collected. Typings were supported by public funds as a part of the Polish National Program for Transplant Medicine Development. HLA frequency data are available in the Allele Frequencies Net Database. |
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| Keywords: | HLA alleles HLA haplotype frequencies Population genetics Genetic diversity NGS typing |
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