Genetic diversity of HLA system in two populations from Tlaxcala,Mexico: Tlaxcala city and rural Tlaxcala |
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| Affiliation: | 1. Histocompatibility Laboratory, Unidad Médica de Alta Especialidad (UMAE) # 6, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, Mexico;2. Laboratory of Biological Anthropology, University of Kansas, Lawrence, KS, USA;3. Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany;4. Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico;5. Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany;6. Immunogenetics Unit, Técnicas Genéticas Aplicadas a la Clínica (TGAC), Mexico City, Mexico;7. Blood Bank, UMAE Hospital de Gineco Obstetricia No. 4 “Luis Castelazo Ayala”, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico;8. Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico;9. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico;10. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA;11. Immunology and Infectology Research Unit, Infectology Hospital, Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico;12. Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán” (INCMNSZ), Mexico City, Mexico |
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| Abstract: | We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1011 Mexicans from the state of Tlaxcala residing in the city of Tlaxcala (N = 181) and rural communities (N = 830), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in Tlaxcala are all of Native American origin. Admixture estimates revealed that the main genetic components are Native American (75.13 ± 1.56% by ML; 69.24% based on of Native American haplotypes) and European (16.10 ± 4.98% by ML; 19.74% of European haplotypes), with a less prominent African genetic component (8.78 ± 4.09% by ML; 4.35% of African haplotypes). |
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| Keywords: | HLA Immunogenetics Population genetics Tlaxcala Admixture |
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