Human leukocyte antigen class I (A,B, C) and class II (DPB1, DQB1, DRB1) allele and haplotype variation in Black South African individuals |
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| Institution: | 1. Centre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Services, 1 Modderfontein Road, Johannesburg 2131, South Africa;2. Faculty of Health Sciences, University of the Witwatersrand, 1 Jan Smuts Avenue, Johannesburg 2000, South Africa;3. School of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, 1 Jan Smuts Avenue, Johannesburg 2000, South Africa |
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| Abstract: | South Africa has a population of 58.78 million, of which 80.7% are Black African individuals, representing 9 predominant ethnic/linguistic groups (Zulu, Xhosa, Pedi, Tswana, South Sotho, Tsonga, Swati, Venda and Ndebele). HIV-1 and Mycobacterium tuberculosis infection are the leading causes of death (7.8% and 5.9%, respectively) in this population group. To provide reference HLA allele and haplotype data for studies of gene-associations with infectious/non-infectious diseases or vaccine development, we have updated previously published HLA class I (A, B, C) and class II DRB1 genotypes and determined high-resolution class II (DPB1, DQB1) genotypes for n = 142 healthy, unrelated Black South African individuals. |
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| Keywords: | HLA class I alleles HLA class II alleles HLA haplotypes South African population Black African |
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