性别决定区盒基因10在黑素瘤中的研究现状及进展

研究表明调节发育过程的基因与通过增殖、侵袭和转移介导肿瘤进展的基因之间存在越来越多的相关性,而针对这些基因的靶向治疗成为当前研究的热点。性别决定区盒基因10(SOX10)是发育生物学中的一个重要转录因子,不仅对黑素细胞的发育及分化产生影响,在黑素瘤的存活、增殖和侵袭中也发挥着重要的作用。现就SOX10在黑素细胞发育和黑素瘤中的作用进行综述,并探讨SOX10在黑素瘤治疗中的潜在方向和前景。

Research status and progress of SOX10 in melanoma

Studies have shown that there are more and more correlations between genes that regulate developmental processes andgenes that mediate tumor progression through proliferation, invasion and metastasis, and targeted therapy for these genes has become ahot spot in current research. Sex determining region Y-box 10 (SOX10) is an important transcription factor in developmental biology. Itnot only affects the development and differentiation of melanocytes, but also plays an important role in the survival, proliferation and in-vasion of melanoma. This article reviews the role of SOX10 in melanocyte development and melanoma, and discusses the potential di-rection and perspectives of SOX10 in the treatment of melanoma.