| 抗氧化剂拮抗甲基汞诱导的脂质过氧化作用研究 |
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| 引用本文： | 安社娟,陈学敏,越飞,杨克敌.抗氧化剂拮抗甲基汞诱导的脂质过氧化作用研究[J].华中医学杂志,2000,24(3):114-115. |
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| 作者姓名： | 安社娟 陈学敏 越飞 杨克敌 |
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| 作者单位： | 1. 同济医科大学环境卫生学教研室武汉 430030;广东药学院环境卫生学教研室
2. 同济医科大学环境卫生学教研室武汉 430030 |
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| 基金项目： | 国家自然科学基金资助项目(No．39470603) |
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| 摘 要： | 目的 探讨抗氧化剂对甲基汞诱导的脂质过氧化的拮抗作用。方法 运用硫代巴比妥酸比色法，检测了谷胱甘肽（ＧＳＨ）、羧乙基锗倍半氧化物（Ｇｅ－１３２）、维生素Ｃ（ＶｉｔＣ）等对甲基汞在体外诱导的大鼠脂质过氧化物（ＬＰＯ）的影响。结果 与阳性对照组相比，２、４、６ｍｍｏｌ／Ｌ ＧＳＨ组大脑、小脑和肝组织匀浆中ＬＰＯ含量均显著下降（Ｐ〈０．０５）；０．５、１．０、１．５、２．０ｇ／Ｌ Ｇｅ－１３２组以及０．
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| 关 键 词： | 甲基汞 抗氧化剂 脂质过氧化作用 甲基汞中毒 |
| 修稿时间： | 2000年3月2日 |
The inhibitory effects of antioxidants on methylmercury-induced lipid peroxidation |
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| An Shejuan,Chen Xuemin,Yue Fei et al.The inhibitory effects of antioxidants on methylmercury-induced lipid peroxidation[J].Central China Medical Journal,2000,24(3):114-115. |
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| Authors: | An Shejuan Chen Xuemin Yue Fei |
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| Institution: | An Shejuan,Chen Xuemin,Yue Fei et al.Department of Environmental Health,Tongji Medical University,Wuhan 430030 |
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| Abstract: | Objective To study the inhibitory effects of antioxidants on methylmercury induced lipid peroxidation (LPO).Methods Thiobarbituric acid colorimetry was used to detect the effects of Glutathion (GSH),2 carboxyethyl germanium sesquioxide (Ge 132) and ascorbid acid (VitC) on methylmercury induced LPO in vitro.Results Compared with the positive control group,the concentrations of LPO in the cerebral and hepatic homogenates in 2,4,6 mmol/L GSH groups were significantly decreased (P<0 05).The concentrations of LPO in the cerebral and hepatic homogenate in 0 5,1 0,1 5,2 0 g/L Ge 132 groups and 0 25,0 30,0 35,0 40 g/L VitC groups were significantly reduced(P<0 05).Conclusion All the three antioxidants with some concentrations could inhibit Methylmercury induced LPO. |
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| Keywords: | Methylmercury Antioxidant Lipid peroxidation |
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