| 补体在缺血再灌注损伤中的作用及机制 |
| |
| 引用本文： | 谭兵,张德纯,汪正清. 补体在缺血再灌注损伤中的作用及机制[J]. 创伤外科杂志, 2007, 9(4): 374-376 |
| |
| 作者姓名： | 谭兵 张德纯 汪正清 |
| |
| 作者单位： | 第三军医大学微生物学教研室,重庆,400038;重庆医科大学临床检验诊断学省部共建教育部重点实验室,病原生物学教研室,重庆,400016;重庆医科大学临床检验诊断学省部共建教育部重点实验室,病原生物学教研室,重庆,400016;第三军医大学微生物学教研室,重庆,400038 |
| |
| 摘 要： | 补体系统在缺血再灌注时通过多种途径被激活,形成大量的活化片段.这些片段在缺血再灌注损伤中发挥着重要作用,它们通过直接作用和对白细胞与内皮细胞的间接作用造成组织器官损伤.目前抗补体的药物虽较多,但真正用于临床的十分有限.笔者现就缺血再灌注时补体的激活途径,活化补体成分引起损伤的作用机制及防治研究进展综述如下.
|
| 关 键 词： | 补体 补体激活 缺血再灌注损伤 |
| 文章编号： | 1009-4237（2007）04-0374-03 |
| 修稿时间： | 2006-11-102007-03-11 |
Role and mechanism of complement in ischemia reperfusion injury |
| |
| TAN Bing,ZHANG De-chun,WANG Zheng-qing. Role and mechanism of complement in ischemia reperfusion injury[J]. Journal of Traumatic Surgery, 2007, 9(4): 374-376 |
| |
| Authors: | TAN Bing ZHANG De-chun WANG Zheng-qing |
| |
| Affiliation: | Department of Microbiology, College of Medicine, Third Military Medical University, Chongqing 400038, China |
| |
| Abstract: | Complement system is activated by all kinds of pathways in ischemia reperfusion(I/R),which results in the formation of many activated fragments.These fragments play an important role in ischemia reperfusion injury.Through direct attack and indirect influence on neutrophil and vascular endothelium,tissue and organ are injured by them.There are a lot of inhibitors of complement at present,however,few of which was applied clinically.The author now give an review on the pathways of complement activation in I/R,mechanism of activated complement components mediated tissue injury and prevention and treatment using complement inhibitors in I/R injury. |
| |
| Keywords: | complement complement activation ischemia reperfusion injury |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
