翼状胬肉切除联合自体角膜缘干细胞移植术后硬性角膜接触镜的干预效果

目的:探讨老年翼状胬肉切除与自体角膜缘干细胞移植术后硬性角膜接触镜的干预效果.方法:选取2015-03/2016-03经我院诊断为单侧翼胬肉老年患者90例90眼进行分组对比研究.观察组45例45眼采用自体角膜缘干细跑移植术后硬性角膜接触镜,对照组45例45眼行单纯自体角膜缘干细胞移植术.两组患者观察指标包括:角膜愈合时间和术后1、3、5、7d时两组患者疼痛程度(VAS评分)、胬肉复发几率.结果:观察组和对照组的角膜刺激症状评分存在统计学差异,观察组评分显著低于对照组患者(P<0.05).对照组患者角膜愈合时间高于观察组患者,差异具有统计学意义(P<0.05);VAS评分显示,术后1、2d时对照组患者高于观察组,两组比较差异具有统计学意义(P<0.05);两组患者胬肉愈合复发几率对比,差异无统计学意义(P>0.05).结论:自体角膜干细胞移植术后结合硬性角膜接触镜对老年翼状胬肉效果明显,患者愈合较快,还可减轻患者术后疼痛感,同时不会增加胬肉复发率.

Effect of rigid corneal contact lens and corneal limbal stem cell transplantation for senile patients with pterygium

AIM: To investigate the effect of rigid contact lens in the treatment after pterygium excision and limbal stem cell transplantation in senile patients.

METHODS: Totally 90 elderly patients diagnosed as unilateral pterygium in our hospital from March 2015 to March 2016 were selected and divided into two groups, observation group and control group, 45 case with 45 eyes in each group. Observation group was treated with limbal stem cell transplantation and rigid contact lens. Control group was treated with limbal stem cell transplantation only. The following indicators were observed and compared: corneal healing time, visual analogue score(VAS)at 1, 3, 5 and 7d after surgery and the recurrence rate of pterygium.

RESULTS: The score on corneal irritation of observation group was significantly lower than that of control group(P<0.05). Control group took more time on corneal healing than observation group(P<0.05). VAS of control group were higher than that of the observation group at 1 and 2d after treatment with significant difference(P<0.05). The recurrence rates of pterygium were not statistically significant between the two groups(P>0.05).

CONCLUSION: Autologous corneal stem cell transplantation combined with rigid contact lens for pterygium in elderly patients is effective with shorter healing time and less pain, and it does not increase the recurrence rate.