百令胶囊联合比阿培南治疗肺气肿的临床研究

目的探讨百令胶囊联合比阿培南治疗肺气肿的临床效果。方法收集2013年1月—2015年12月在河北大学附属医院接受治疗的104例肺气肿患者,随机分为对照组和治疗组,每组各52例。对照组患者静脉滴注注射用比阿培南,0.6 g溶于100 m L生理盐水,2次/d。治疗组在对照组的基础上口服百令胶囊,5~10粒/次,3次/d。两组患者持续治疗8周。治疗后评价两组患者临床疗效,同时比较分析两组患者治疗前后第1秒呼气量(FEV1)、用力肺活量(FVC)、肺活量(VC)、最大通气量(MVV)、动脉血气饱和度、二氧化碳分压(pCO_2)、氧分压(pO_2)、动脉氧分压、氧合指数、细菌清除率和血清C反应蛋白(CRP)改变。结果治疗后,对照组的有效率为78.85%,显著低于治疗组的88.46%,两组总有效率比较差异具有统计学意义(P0.05)。治疗后,两组患者FEV1、FVC、VC和MVV水平均显著升高(P0.05),且治疗后治疗组患者上述肺功能指标升高的更显著(P0.05)。治疗后,两组氧合指数、pO_2、动脉氧分压、动脉血气饱和度明显升高,pCO_2明显下降,同组治疗前后比较差异具有统计学意义(P0.05);且治疗后治疗组患者血气指标结果明显优于对照组,两组治疗后比较差异具有统计学意义(P0.05)。治疗后,治疗组细菌清除率明显高于对照组,且治疗组血清CRP含量明显比对照组低,两组细菌清除效果和CRP比较差异具有统计学意义(P0.05)。结论百令胶囊联合比阿培南能够明显提高肺气肿患者的治疗效果,对于改善肺气肿患者肺部功能、降低体内炎症水平具有重要作用。

Clinical study on Bailing Capsules combined with biapenem in treatment of emphysema

Objective To explore the clinical effect of Bailing Capsules combined with biapenem in treatment of emphysema. Methods Patients (104 cases) with emphysema in Affiliated Hospital of Hebei University from January 2013 to December 2015 were randomly divided into control and treatment groups, and each group had 52 cases. Patients in the control group were iv administered with Biapenem for injection, 0.6 g added into normal saline 100 mL, twice daily. Patients in the treatment group were po administered with Bailing Capsules on the basis of the control group, 5 - 10 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the changes of FEV₁, FVC, VC, MVV, arterial blood gas saturation, pCO₂, pO₂, arterial oxygen pressure, oxygenation index, bacterial eradication rate, and CRP in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control was 78.85%, which was significantly lower than 88.46% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the FEV₁, FVC, VC, and MVV levels in two groups were significantly increased (P < 0.05). And the pulmonary function indexes in the treatment group were increased more significantly than those in the control group (P < 0.05). After treatment, oxygenation index, pO₂, and arterial oxygen pressure in two groups were significantly increased, and pCO₂ of the treatment group was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). The blood gas indexes in treatment group were significantly better than those in the control group, and there were differences between two groups (P < 0.05). After treatment, the bacterial eradication rate in the treatment group was significantly higher than that in the control group, at the same time CRP in treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Bailing Capsules combined with imipenem can significantly improve the treatment effect of patients with emphysema, which has an important role of improving lung function and reducing inflammation level of patients with emphysema.