麦角新碱联合垂体后叶注射液治疗产后出血的疗效观察

目的探讨马来酸麦角新碱注射液联合垂体后叶注射液治疗产后出血的临床疗效。方法选取2015年1月—2017年1月在郑州大学第五附属医院接受治疗的产后出血患者86例,所有入选患者采用随机数字表法随机分为对照组和治疗组,每组各43例。对照组于分娩后静脉滴注垂体后叶注射液,6 U加入到5%葡萄糖注射液500 m L中,滴速0.02~0.04 U/min。治疗组在对照组基础上肌肉注射马来酸麦角新碱注射液0.2 mg,必要时可2~4 h重复注射1次,最多5次。观察两组的临床疗效,比较两组的产后出血量和止血时间。结果治疗后,对照组和治疗组的总有效率分别为81.40%、95.35%,两组比较差异有统计学意义(P0.05)。用药后30 min、2 h、24 h后,治疗组产后出血量均明显少于对照组,两组比较差异具有统计学意义(P0.05);治疗后,治疗组止血时间明显短于对照组,两组比较差异具有统计学意义(P0.05)。结论马来酸麦角新碱注射液联合垂体后叶注射液治疗产后出血具有较好的临床疗效,可减少出血量,缩短止血时间,具有一定的临床推广应用价值。

Clinical observation of ergometrine combined with Posterior Pituitary Injection in treatment of postpartum hemorrhage

Objective To investigate the clinical effect of Ergometrine Maleate Injection combined with Posterior Pituitary Injection in treatment of postpartum hemorrhage. Methods Patients (86 cases) with postpartum hemorrhage in the Fifth Affiliated Hospital of Zhengzhou University from January 2015 to January 2017 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were iv administered with Posterior Pituitary Injection after childbirth, 6 U added into 5% glucose solution 500 mL, drop speed 0.02 - 0.04 U/min. Patients in the treatment group were iv administered with Ergometrine Maleate Injection for 0.2 mg on the basis of the control group, if necessary, 2 - 4 h repeated one time, up to 5 times. After treatment, the clinical efficacies were evaluated, and the amount of postpartum hemorrhage and hemostasis time in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.40% and 95.35%, respectively, and there was difference between two groups (P < 0.05). After treatment for 30 min, 2 h, and 24 h, the amount of postpartum hemorrhage in the treatment group was significantly lower than that in the control group, and there was difference between two groups (P < 0.05). After treatment, hemostasis time in the treatment group was significantly shorter than that in the control group, and there was difference between two groups (P < 0.05). Conclusion Ergometrine Maleate Injection combined with Posterior Pituitary Injection has clinical curative effect in treatment of postpartum hemorrhage, and can reduce the amount of bleeding, and shorten hemostasis time, which has a certain clinical application value.