固肾安胎丸联合保胎无忧片治疗早期先兆流产的疗效观察

目的探讨固肾安胎丸联合保胎无忧片治疗早期先兆流产的临床疗效。方法选取2014年4月—2016年8月衡水市第二人民医院收治的早期先兆流产患者178例,随机分为对照组和治疗组,每组各89例。对照组患者口服保胎无忧片,4片/次,3次/d。治疗组在对照组治疗基础上口服固肾安胎丸,1袋/次,3次/d。两组均连续治疗4周。观察两组的临床疗效,比较两组治疗前后血人绒毛膜促性腺激素(β-HCG)和孕酮的变化情况。于妊娠12周及治疗后12周对患者进行随访,观察其远期疗效。结果治疗后,对照组和治疗组的总有效率分别为75.28%、87.64%,两组比较差异具有统计学意义(P0.05)。治疗后,两组β-HCG和孕酮水平均显著上升,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,治疗组β-HCG和孕酮水平高于对照组,两组比较差异具有统计学意义(P0.05)。妊娠12周对照组和治疗组的有效率分别为70.79%、83.15%。于治疗后12周两组有效率分别为69.66%、79.78%,两组妊娠12周,治疗后12周的有效率比较差异均有统计学意义(P0.05)。结论固肾安胎丸联合保胎无忧片治疗早期先兆流产具有较好的临床疗效,可提高血清β-HCG和孕酮水平,具有一定的临床推广应用价值。

Clinical observation of Gushen Antai Pills combined with Baotai Wuyou Tablets in treatment of early threatened abortion

objective To explore the clinical effect of Gushen Antai Pills combined with Baotai Wuyou Tablets in treatment of early threatened abortion.Methods Patients (178 cases) with early threatened abortion in Hengshui Second Hospital from April 2014 to August 2016 were randomly divided into control and treatment groups, and each group had 89 cases. Patients in the control group were poadministered with Baotai Wuyou Tablets, 4 tablets/ time, three times daily. Patients in the treatment group werepo administered with Gushen Antai Pills, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the changes ofβ-HCG and progesterone in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 75.28% and 87.64%, respectively, and there was difference between two groups (P < 0.05). After treatment,β-HCG and progesterone in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment,β-HCG and progesterone in the treatment group were higher than those in the control group, and there were differences between two groups (P < 0.05). The efficacies in the control and treatment groups were 70.79% and 83.15% at the 12th week of pregnancy, respectively, while 12 weeks after treatment, the efficacies in two groups were 69.66% and 79.78%, respectively, and there was difference between two groups (P < 0.05). Conclusion Gushen Antai Pills combined with Baotai Wuyou Tablets has significant clinical efficacy in treatment of early threatened abortion, and can increases levels ofβ-HCG and progesterone, which has a certain clinical application value.