激光共焦显微镜与角膜组织刮片检查在真菌性角膜炎中应用的比较

目的:对比分析激光共焦显微镜检查与角膜组织刮片检查在真菌性角膜炎诊断中的应用.方法:选择2016-05/08来我院治疗的拟诊为真菌性角膜炎患者77例77眼,同时行激光共焦显微镜检查及角膜组织刮片检查,观察图像特点,对比分析两种方法真菌检出率情况.结果:所有患者中,激光共焦显微镜检出阳性66眼,阴性11眼,检出率为86%;角膜组织刮片检查确诊阳性51眼,阴性26眼,检出率为66%,两者比较差异具有统计学意义(P<0.05).结论:激光角膜共焦显微镜检查的安全性和敏感性相对较高,如果能将激光角膜共焦显微镜检查与角膜组织刮片检查联合应用于临床,对提高真菌性角膜炎患者的诊断率具有重要意义.

Comparative analysis of laser confocal microscopy and corneal smear in the diagnosis of fungal keratitis

AIM: To comparatively analyze the application of laser confocal microscopy and corneal smear in the diagnosis of fungal keratitis.

METHODS: Totally 77 patients(77 eyes)diagnosed as fungal keratitis were selected. Laser confocal microscopy and corneal smear examination were performed to observe the characteristics of the images, and the detection rate of fungus were compared between the two methods.

RESULTS: Of the 77 patients, 66 eyes(86%)were positive and 11 eyes were negative detected by laser confocal microscopy; 51 eyes(66%)were positive and 26 eyes were negative detected by corneal smear examination, the difference was statistically significant compared between two group(P<0.05).

CONCLUSION: Laser corneal confocal microscopy is relatively safe and sensitive. If combined the application of laser corneal confocal microscopy and corneal smear examination in clinical, the diagnosis rate of fungal keratitis may be improved.