二苯乙烯类化合物E1对2型糖尿病大鼠心肌病变的影响

目的 :观察灌胃给予二苯乙烯类化合物 (E1 )对实验性非胰岛素依赖型糖尿病 (NIDDM)大鼠血糖、血脂及心肌并发症的影响。方法 :通过尾静脉注射小剂量链佐星 (链脲佐菌素 ,streptozotocin ,STZ)损伤大鼠胰岛细胞造成其糖耐量异常 ,继而喂以高糖_高脂饲料 ,诱发动物肥胖形成的 2型糖尿病大鼠模型 ;电镜技术。结果 :灌胃给予二苯乙烯类化合物 (E1 )能明显降低NIDDM大鼠空腹血糖及血清甘油三酯、胆固醇含量 ,减轻NIDDM大鼠心肌病变程度。结论 :二苯乙烯类化合物 (E1 )具有显著的降血糖、降血脂作用 ,并可减轻NIDDM大鼠心肌病变程度。

The effect of stilbenoid(E1) on cardiac complication of rats with experimental non-insulin-dependent diabetes mellitus

Objective:To observe the effect of orally administered stilbenoid(E 1) on levels of blood glucose,blood lipid and cardiac complication of rats with experimental non_insulin_dependent diabetes mellitus(NIDDM).Methods:The rat model of NIDDM was established by tail_vein injection of a low dose of freshly prepared streptozotocin(STZ, 25*!mg/kg) to injure the pancreatic islet cells and impair the glucose tolerance.Then, NIDDM rats were fed with high glucose_high fat diets in order to make them obese. At the same time,electron microscopy was carried out. Results: Stilbenoid(E 1) could significantly lower levels of fasting blood glucose,serum triglyceride and cholesterol and alleviate cardiac pathological changes in NIDDM rats.Conclusions:Stilbenoid(E 1) has marked glucose_lowering and lipid_lowering effects,and can alleviate cardiac pathological changes in NIDDM rats.