精神分裂症患者手术治疗前后海马磁共振质子波谱成像的研究

目的 探讨精神分裂症患者海马磁共振质子波谱(MRS)的变化特点以及立体定向手术治疗对海马磁共振质子波谱的影响.方法 应用磁共振质子波谱成像技术,对20例正常人和20例精神分裂症患者在手术治疗前、后检测双侧海马NAA/Cr和CHO/Cr的比值并进行统计分析.结果 患者组在手术治疗前的NAA/Cr值低于正常对照组,患者组在手术治疗前的CHO/Cr值高于正常对照组(P<0.01).患者组行手术治疗前与手术治疗后6个月时其双侧海马的NAA/Cr和CHO/Cr比值无显著差异(P>0.05).结论 精神分裂症患者的海马可能存在神经元的损害和细胞膜的代谢异常,立体定向手术对精神分裂症患者的细胞膜代谢无显著影响.

Proton magnetic resonance spectroscopic imaging of the hippocampus in schizophrenia patients before and after surgery

Objective To explore the features of proton magnetic resonance spectroscopy (1H-MRS) of the hippocampus in schizophrenia patients before and after stereotactic neurosurgery. Methods 1H-MRS was performed to determine NAA/Cr and CHO/Cr ratioson the bilateral hippocampal regions before and after stereotactic neurosurgery in 20 schizophrenia patients,with 20 healthy individuals as the controls. Results The NAA/Cr ratio in the hippocampal regions was significantly lower and the CHO/Cr ratio significantly higher ...