间充质干细胞移植治疗职业性慢性苯中毒的效果观察与护理

目的观察间充质干细胞(mesenchymal stem cell,MSC)移植治疗职业性慢性苯中毒效果和探讨其护理措施。方法回顾分析和总结5例职业性慢性苯中毒患者采用48例次MSC治疗和护理方法,并观察其治疗前后的效果。结果 5例患者治疗后白细胞(white blood cell,WBC)、血红蛋白(hemoglobin,Hb)、中性粒细胞(neutrophil,N)、血小板(platelet,PLT)均有明显升高,其中WBC和N与治疗前比较,差异具有统计学意义(均P0.05);治疗后患者骨髓增生活跃;5例均无发生不良反应。结论 MSC治疗职业性慢性苯中毒是安全有效的。密切观察病情变化,严格执行保护性隔离和心理护理,做好相关并发症预见性护理措施,对确保MSC移植术有效顺利进行和提高治疗效果具有积极意义。

Effect observation and nursing care on occupational chronic benzene poisoning treatment by Mesenchymal stem cell transplantation

Objective To study the curative effect of mesenchymal stem cells（MSC）transplantation on occupational chronic benzene poisoning and summarize the nursing measures.Methods The clinical data of 5 patients with occupational chronic benzene poisoning treated with MSC transplantation for 48 times totally were retrospectively reviewed for the purpose of investigating the curative effects and summing up the nursing measures.Results After transplantation,the levels of white blood cells,hemoglobin and neutrophil,platelet were all increased significantly.The differences in white blood cells and neutrophil were significant between pre-and post-transplantation（P＆lt;0.05）.Bone marrow hyperplasia was active after treatment.No adverse reactions were observed in all of the patients.Conclusion MSC is safe and effective in treating occupational chronic benzene poisoning.Observing patient’s conditions closely,implementing protective isolation and psychological nursing strictly and doing predictive nursing measures are of significance for success of MSC transplantation and improvement of the curative effect.