| 半合成苯甲醛类衍生物镇痛作用研究 |
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| 引用本文： | 尹卫平 马忠敏. 半合成苯甲醛类衍生物镇痛作用研究[J]. 河南医学研究, 1996, 5(1): 30-32 |
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| 作者姓名： | 尹卫平 马忠敏 |
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| 作者单位： | 新乡医学院 |
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| 摘 要： | β－环糊精苯甲醛（β－ＣＤＢＡ）和４，６－０－叉基－Ｄ吡喃葡萄糖（ＢＧ）是已知的苯甲醛类化合物。我们以无花果提取物为原料，制备的半合成品β－ＣＤＢＡ和ＢＧ，用小鼠热板法实验证实有镇痛作用。其镇痛效果与吗啡相比，痛阈值较吗啡低，但维持时间较久。
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| 关 键 词： | β－环糊精苯甲醛，4，6－0－苄叉基－D－吡喃葡萄糖，半合成，镇痛作用 |
THE RESEARCH ON ANALGESIC ACTIVITY OF BENZALDEHYDE DERIVATIVE FOR SEMI-SYNTHESIS |
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| Abstract: | By using hot plane excitment test of mice,β-cyclodextrin benzaldehyde (β-CDBA) and 4,6-0-benzyliden-D-glucose (BG)have been found to have analgesic activitywhich two synthesic compounds with nature figs crude extracts. In fact,β-CDBA and BG areknown compounds of benzaldehyde derivative. The data obtained here proved that theirthreshold value of pain is lower than morphine,the uphold time of inhibition pain is longerthan morphine. |
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| Keywords: | β-cyclodextrin benzaldehyde 4 6-0-benzylidene-D-glucose semi-synthesis analgesic activity |
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