| 抗癌药物脂质体制剂药代动力学的研究进展 |
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| 引用本文： | 莫凡,肖学凤,乔晓莉. 抗癌药物脂质体制剂药代动力学的研究进展[J]. 齐鲁药事, 2009, 28(8): 482-485 |
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| 作者姓名： | 莫凡 肖学凤 乔晓莉 |
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| 作者单位： | 天津中医药大学,天津,300193 |
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| 摘 要： | 目的对抗癌药物脂质体制剂的药代动力学研究成果进行综述。方法参阅、归纳、总结相关文献,根据作用机制的不同对抗癌药物进行分类,分别阐述这些药物脂质体制剂的药代动力学研究概况。结果与结论脂质体制剂具有靶向性、缓释性的特点,能提高血药浓度和药物的生物利用度,使药物的消除速率慢于游离药物。脂质体制剂能够改善抗癌药物的治疗效果,并能降低药物的毒副作用。
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| 关 键 词： | 药代动力学 脂质体 抗癌药物 |
Pharmacokinetics's research advancement of anticancer drugs's liposome preparation |
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| MO Fan,XIAO Xue-feng,QIAO Xiao-li. Pharmacokinetics's research advancement of anticancer drugs's liposome preparation[J]. qilu pharmaceutical affairs, 2009, 28(8): 482-485 |
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| Authors: | MO Fan XIAO Xue-feng QIAO Xiao-li |
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| Affiliation: | Tianjin University of Traditional Chinese Medicine;Tianjin 300193;1.Nankai Hospital of Tianjin;Tianjin 300100 |
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| Abstract: | OBJECTIVE Reviewed pharmacokinetics＇ s research result of anticancer drugs＇ s liposome preparation. METHODS Read and summarized the pertinent literature,classified antieancer preparation. RESULTS and CONCLUSION Liposome preparation has the feature called target and delayed-release,it can elevate blood drug level and drugs＇s bioavail- ability,it also make drugs＇s elimination rate become slower than the liberative drugs. Liposome preparation can improve the therapeutic efficacy of anticancer drugs,and it can degrade the drug＇s toxicity and side effect. |
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| Keywords: | Pharmacokinetics liposome anticancer drugs |
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