首页 | 本学科首页   官方微博 | 高级检索  
检索        


Morphological characteristics of malignant T-cell lymphomas in baboons
Authors:Lelita A Yakovleva  Karl Lennert  Merab G Chikobava  Leonora V Indzhiia  Igor N Klotz  Boris A Lapin
Institution:(1) Institute of Experimental Pathology and Therapy, Sukhumi, Abkhazia, Georgia;(2) Institute of Pathology, Kiel, Germany;(3) Zentrum für Pathologie und Angewandte Krebsforschung, Niemannsweg 11, W-2300 Kiel 1, Germany
Abstract:Fifteen cases of generalized peripheral T-cell non-Hodgkin's lymphoma in baboons were phenotyped immunologically and morphologically. Using the updated Kiel classification the cases included low-grade and high-grade lymphomas and low-grade lymphomas that had transformed into high-grade lymphomas. In the low-grade group there were seven cases of lymphocytic type, partly corresponding to chronic lymphocytic leukaemia of T type and to T-zone lymphoma in man. In addition there were four cases of prolymphocytic-lymphocytic type, which show large nodules (ldquoproliferation centresrdquo) and which have no equivalent in the Kiel classification. In four cases there was a progression to an immunoblastic lymphoma and in one case to a large cell anaplastic lymphoma. In addition, three cases of large cell anaplastic lymphoma without a low-grade component were found. Both the immunoblastic lymphomas and the large cell anaplastic lymphomas corresponded well with the same types in the Kiel classification. The cases of large cell anaplastic lymphoma were also CD30 positive. Most of these lymphomas were CD4 positive, but there were rare cases that were either CD8 positive, showed both CD4 and CD8 positivity or had lost both antigens. Antigens associated with cell activation were often revealed. All but one baboon had antibodies in the blood against the retrovirus STLV-1 (simian T-cell leukaemia virus 1), which is very similar to human T-cell leukaemia virus 1 (HTLV-1) in man. Despite this virological resemblance, the morphology of these T-cell lymphomas does not resemble that of the HTLV-1-positive Japanese T-cell lymphomas but is like that of the HTLV-1-negative European cases.
Keywords:Baboon malignant lymphoma  Peripheral T-cell lymphoma  Simian T-cell leukaemia virus
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号