18F-FDG PET/CT利尿延迟显像膀胱放射性廓清效果的影响因素

目的 探讨¹⁸F-FDG PET/CT利尿延迟显像膀胱放射性廓清效果的影响因素。方法 回顾性收集85例盆腔利尿延迟显像患者的PET/CT资料，测量膀胱常规及利尿延迟显像最大标准化摄取值（SUV_max），记录延迟时间；分析常规显像膀胱SUV_max、呋塞米注射途径（静脉注射或肌内注射）、延迟时间、年龄、性别因素对利尿延迟显像膀胱SUV_max的影响。结果 根据呋塞米注射途径不同，分为静脉注射组（n=34）和肌内注射组（n=51），2组利尿延迟显像膀胱SUV_max分别为3.10（2.60，3.45）和2.90（2.30，3.90），差异无统计学意义（Z=-0.894，P=0.372）；延迟显像时间分别为¹⁸F-FDG注射后（215.00±30.03）min和（198.43±25.19）min，差异有统计学意义（t=-2.655，P=0.010）。2组间年龄差异无统计学意义（t=1.150，P=0.253），2组中不同性别患者间延迟显像膀胱SUV_max差异均无统计学意义（P均>0.05）。静脉注射组和肌内注射组利尿延迟显像膀胱SUV_max与延迟时间和患者年龄均无明显相关性。结论 注射¹⁸F-FDG后充分水化、应用呋塞米利尿，约180 min行盆腔延迟显像能显著降低膀胱放射性，患者年龄、性别、呋塞米注射途径对于膀胱放射性廓清效果无明显影响。

Impact factors of bladder radioactive washout on 18F-FDG PET/CT diuretic delayed imaging

Objective To investigate the impact factors of bladder radioactive washout on ¹⁸F-FDG PET/CT diuretic delayed imaging. Methods PET/CT data with pelvic delayed imaging of 85 patients were retrospectively analyzed. Maximal standardized uptake value(SUV_max) of the bladder on routine and delayed imaging and delayed time were measured. The influence of the bladder SUV_max on routine imaging, furosemide injection approaches (transvenous or intramuscular), delayed time, patient''s age and gender on bladder SUV_max on delayed imaging were respectively analyzed. Results The patients were divided into transvenous group (n=34) and intramuscular group (n=51). The SUV_max of bladder on delayed imaging was 3.10 (2.60, 3.45) of transvenous group and 2.90 (2.30, 3.90) of intramuscular group (Z=-0.894, P=0.372). The delayed time was (215.00±30.03)min in transvenous group and (198.43±25.19)min in intramuscular group after ¹⁸F-FDG injection (t=-2.655, P=0.010). No difference of patients'' age was found between the 2 groups (t=1.150, P=0.253). SUV_max of bladder on delayed imaging had no difference between different genders in both group (both P>0.05). SUV_max of bladder on delayed imaging had no correlation to delay time nor age in both group (all P>0.05). Conclusion The radioactivity of the bladder decreases dramatically on delayed imaging performed about 180 min after ¹⁸F-FDG injection with prior enough hydration and furosemide diuresis. Patient''s age, gender and furosemide injection approaches has no obvious impact on bladder radioactive washout.