人脑血氧水平依赖信号有源仿真和成像

目的 对人脑血氧水平依赖（BOLD）信号进行仿真并成像，以之作为金标准和标准信号，基于信号成像灰度幅值变化评价脑功能磁共振成像（fMRI）质量和检出率。方法 设计一种能有源模拟人脑BOLD的激发电路，实现不同电流幅值、不同频率、不同占空比的稳定矩形波输出，在时间域内仿真人脑BOLD信号。结果 3台不同型号、不同场强MR皆有稳定的矩形波输入，且检出率一致。结论 同一设备对同一刺激模式检出率相近，可作为已知且确定信号的参考标准，定量分析MR系统对BOLD信号的检出率和一致性。

Active simulation and imaging of human brain blood oxygenation level dependent signal

Objective To active simulation and imaging of human brain blood oxygenation level dependent (BOLD) signal, taken which as gold standard and standard signal to detect the quality and detection rate of brain MRI functional magnetic resonance imaging (fMRI) based on the changes of gray amplitude of BOLD signals during imaging. Methods A new excitation circuit that could simulate the BOLD of the human brain was used to achieve the stable rectangular wave output of different current amplitude, different frequency and different space ratio, and the BOLD signal of the human brain in the time domain was simulated. Results Stable rectangular wave input and consistent detection rate were obtained with 3 different MR devices with different field strength. Conclusion The same device has similar detection rate for the design of the same stimulus model, which can be used as the reference standard of the known and determined signal to analyze the detection rate and consistency of BOLD signal.