| 玉屏风颗粒抑制鼻咽癌作用实验研究 |
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| 引用本文： | 罗阳旭,蔡璐,郭静,马安德,罗奇志. 玉屏风颗粒抑制鼻咽癌作用实验研究[J]. 药学研究, 2020, 39(8): 435-439 |
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| 作者姓名： | 罗阳旭 蔡璐 郭静 马安德 罗奇志 |
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| 作者单位： | 南方医科大学公共卫生学院卫生检测中心,广东 广州510515;南方医科大学肿瘤研究所,广东 广州510515;广东环球制药有限公司,广东 佛山528303;南方医科大学法医学院法医毒物学系,广东 广州510515 |
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| 摘 要： | 目的 探讨玉屏风颗粒对鼻咽癌的治疗作用。方法 采用人鼻咽癌CNE-2细胞模型和裸鼠体内异种移植瘤模型，研究玉屏风颗粒对CNE-2细胞存活率和荷鼻咽癌裸鼠肿瘤体积、体重及生存期的影响。结果 玉屏风颗粒对CNE-2细胞有明显的抑制作用。与对照组相比，玉屏风颗粒组[4 g·(kg·d)-1]能显著增加荷鼻咽癌裸鼠体重，并抑制肿瘤的生长；顺铂组（每周6 mg·kg-1）及玉屏风颗粒+顺铂组[4 g·(kg·d)-1+每周6 mg·kg-1]则显著降低荷鼻咽癌裸鼠体重，并抑制肿瘤的生长。玉屏风颗粒单独使用和与顺铂联用均能显著延长裸鼠的生存期。结论 玉屏风颗粒具有抑制鼻咽癌作用，能显著延长荷鼻咽癌裸鼠生存期，提高生存质量，未发现明显毒副作用。
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| 关 键 词： | 玉屏风颗粒 鼻咽癌 CNE-2细胞 荷鼻咽癌裸鼠 生存期 |
Experimental study on the inhibitory activity of Yupingfeng Granules on nasopharyngeal carcinoma |
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| LUO Yangxu,CAI Lu,GUO Jing,MA Ande and LUO Qizhi. Experimental study on the inhibitory activity of Yupingfeng Granules on nasopharyngeal carcinoma[J]. Journal of Pharmaceutical Research, 2020, 39(8): 435-439 |
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| Authors: | LUO Yangxu CAI Lu GUO Jing MA Ande LUO Qizhi |
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| Affiliation: | 1.Hygiene Detection Center, School of Public Health, Southern Medical University, Guangzhou 510515, China; 2.Cancer Research Institute, Southern Medical University, Guangzhou 510515, China; 3. Guangdong Medi-World Pharmaceutical Co., Ltd., Foshan 528303, China;4.Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China,1.Hygiene Detection Center, School of Public Health, Southern Medical University, Guangzhou 510515, China; 2.Cancer Research Institute, Southern Medical University, Guangzhou 510515, China; 3. Guangdong Medi-World Pharmaceutical Co., Ltd., Foshan 528303, China;4.Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China,1.Hygiene Detection Center, School of Public Health, Southern Medical University, Guangzhou 510515, China; 2.Cancer Research Institute, Southern Medical University, Guangzhou 510515, China; 3. Guangdong Medi-World Pharmaceutical Co., Ltd., Foshan 528303, China;4.Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China,1.Hygiene Detection Center, School of Public Health, Southern Medical University, Guangzhou 510515, China; 2.Cancer Research Institute, Southern Medical University, Guangzhou 510515, China; 3. Guangdong Medi-World Pharmaceutical Co., Ltd., Foshan 528303, China;4.Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China and 1.Hygiene Detection Center, School of Public Health, Southern Medical University, Guangzhou 510515, China; 2.Cancer Research Institute, Southern Medical University, Guangzhou 510515, China; 3. Guangdong Medi-World Pharmaceutical Co., Ltd., Foshan 528303, China;4.Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China |
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| Abstract: | Objective To investigate the inhibitory activity of Yupingfeng Granules (YPF) on nasopharyngeal carcinoma.Methods Human nasopharyngeal carcinoma CNE-2 cell lines and a xenograft nude mice model were used. After drug treatment, survival rates of CNE-2 cell lines, tumor volumes, body weights and survival time of the xenograft model were measured.Results YPF treatment showed a significant inhibitory effect on CNE-2 cell lines. In the xenograft nude mice model, YPF treatment significantly inhibited tumor growth while increased body weights when compared with the control group. Cisplatin treatment and the combination of cisplatin and YPF significantly inhibited tumor growth but decreased body weights. Both YPF treatment and the combination of cisplatin and YPF could significantly prolong the survival time of the xenograft nude mice model.Conclusion Our results indicated that YPF was a potent growth inhibitor for nasopharyngeal carcinoma, which could prolong survival time and improve life quality without evident toxic and side effects. |
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| Keywords: | Yupingfeng Granules Nasopharyngeal carcinoma CNE-2 cell lines Xenograft nude mice model Survival time |
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