两种不同药物对骨质疏松性椎体骨折术后老年患者疗效的影响

目的研究丹参注射液联合仙灵骨葆胶囊对骨质疏松性椎体骨折术后老年患者血清胰岛素生长因子-1(insulin growth factor-1,IGF-1)及碱性成纤维细胞生长因子(basic fibroblast growth factor,b FGF)水平的影响。方法选取我院于2017年6月至2018年10月收治的123例老年骨质疏松性椎体骨折患者,依据随机数字表法分为观察(62例)和对照(61例)两组。两组患者均行经皮椎体成形术(PVP)治疗,对照组患者服用仙灵骨葆胶囊(持续用药3个月),观察组患者在对照组基础上使用丹参注射液(持续用药1周)。比较两组患者的治疗效果、骨折愈合情况,以及VAS评分和血清b FGF及IGF-1在不同时间点水平变化,统计两组并发症发生情况。结果观察组患者治疗有效率(95.00%)显著高于对照组(83.33%),差异有统计学意义(P0.05)。治疗后6个月两组患者骨密度显著增加,而椎体后凸Cobb角显著降低,且观察组患者改善情况显著优于对照组(P0.05)。两组患者经治疗后VAS评分显著降低,血清b FGF、IGF-1水平显著增加,其中观察组患者VAS评分、血清b FGF、IGF-1水平在治疗2周、4周、6周的改善程度均优于对照组(P0.05)。两组患者并发症发生率的差异无统计学意义(P0.05)。结论丹参注射液联合仙灵骨葆胶囊可增强PVP对老年骨质疏松性椎体骨折患者的疗效,可通过提高血清b FGF及IGF-1水平促进骨折修复,从而加快骨折愈合,降低疼痛。

Efficacy of two different drugs on osteoporotic vertebral fractures in elderly patients

Objective To study the effect of Danshen injection combined with Xianlinggubao capsule on serum bFGF and IGF-1 levels in elderly patients with osteoporotic vertebral fractures after operation. Methods One hundred and twenty-three elderly patients with osteoporotic vertebral fractures treated in our hospital from June 2017 to October 2018 were divided into observation group (62 cases) and control group (61 cases) according to random digital table. The patients in the two groups were treated with PVP. Patients in the control group received Xianlinggubao capsule (continuous administration for 3 months), and patients in the observation group received Danshen injection (continuous administration for 1 week) in addition to the treatment of the control group. The therapeutic efficacy, fracture healing, VAS score, and the changes of serum bFGF and IGF-1 levels at different time points were compared between the two groups. The occurrence of complications in the two groups was recorded. Results The effective rate of treatment in the observation group (95.00%) was significantly higher than that in the control group (83.33%), with significant difference (P <0.05). After 6 months of the treatment, bone mineral density of the two groups increased significantly, while the Cobb angle of kyphosis decreased significantly. The improvement of the patients in the observation group was significantly better than that in the control group (P <0.05). After the treatment, VAS score of the two groups decreased significantly, and the serum levels of bFGF and IGF-1 level increased significantly. VAS score and serum levels of bFGF and IGF-1 in the observation group were better than those in the control group at 2 weeks, 4 weeks, and 6 weeks after the operation. There was no significant difference in the incidence of complications between the two groups (P?0.05). Conclusion Danshen injection combined with Xianlinggubao capsule enhances the curative effect of PVP on osteoporotic vertebral fracture in the elderly patients, and promotes fracture healing by increasing serum bFGF and IGF-1 levels, so as to speed up fracture healing and to reduce pain.