| VEGFR2靶向超声造影诊断乳腺癌研究进展 |
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| 引用本文： | 张欢,阎锋,王红,黄建波,彭玉兰.VEGFR2靶向超声造影诊断乳腺癌研究进展[J].中国医学影像技术,2019,35(3):463-466. |
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| 作者姓名： | 张欢 阎锋 王红 黄建波 彭玉兰 |
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| 作者单位： | 四川大学华西医院超声科, 四川 成都 610041,四川大学华西医院超声科, 四川 成都 610041;四川大学华西医院临床超声影像药物研究室, 四川 成都 610041,四川大学华西医院超声科, 四川 成都 610041;四川大学华西医院临床超声影像药物研究室, 四川 成都 610041,四川大学华西医院临床超声影像药物研究室, 四川 成都 610041,四川大学华西医院超声科, 四川 成都 610041 |
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| 基金项目： | 国家自然科学基金面上项目（81571694）。 |
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| 摘 要： | 肿瘤新生血管对乳腺癌的生长及转移具有重要作用。血管内皮细胞生长因子受体2（VEGFR2）在肿瘤新生血管内皮细胞中过量表达。超声分子显像（USMI）是通过靶向超声造影剂识别病变血管内皮细胞特异性表达靶点的新技术。大量实验及初步临床研究发现，以VEGFR2为靶向超声造影剂的USMI可用于诊断乳腺癌。本文对VEGFR2靶向超声造影诊断乳腺癌的研究进展进行综述。
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| 关 键 词： | 乳腺肿瘤 超声检查 血管内皮生长因子受体 造影剂 |
| 收稿时间： | 2018/6/28 0:00:00 |
| 修稿时间： | 2018/10/1 0:00:00 |
Progresses of VEGFR2 targeted ultrasound contrastimaging in diagnosis of breast cancer |
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| ZHANG Huan,YAN Feng,WANG Hong,HUANG Jianbo and PENG Yulan.Progresses of VEGFR2 targeted ultrasound contrastimaging in diagnosis of breast cancer[J].Chinese Journal of Medical Imaging Technology,2019,35(3):463-466. |
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| Authors: | ZHANG Huan YAN Feng WANG Hong HUANG Jianbo and PENG Yulan |
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| Institution: | Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China,Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China;Clinical Ultrasound Imaging Drug Research Lab, West China Hospital, Sichuan University, Chengdu 610041, China,Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China;Clinical Ultrasound Imaging Drug Research Lab, West China Hospital, Sichuan University, Chengdu 610041, China,Clinical Ultrasound Imaging Drug Research Lab, West China Hospital, Sichuan University, Chengdu 610041, China and Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China |
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| Abstract: | Tumor angiogenesis plays an important role in growth and metastasis of breast cancer. Vascular endothelial growth factor receptor 2 (VEGFR2) is over-expressed on tumor neo-angiogenesis endothelial cells. Ultrasound molecular imaging (USMI) is a new technology to identify the specific expression of vascular endothelial cells by targeted ultrasound contrast agent (tUCAs). A large number of experimental and preliminary clinical studies have demonstrated that USMI with VEGFR2 tUCAs could be used to diagnose breast cancer. The progresses of VEGFR2 targeted ultrasound contrast imaging in the diagnosis of breast cancer were reviewed in this article. |
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| Keywords: | breast neoplasms ultrasonography vascular endothelial growth factor receptor contrast media |
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