嘌呤受体P2Y在免疫炎症中的功能研究进展

P2Y受体（P2YRs）是一类由胞外核苷酸活化的G蛋白偶联受体（GPCRs），从属于嘌呤受体家族。P2Y受体的生理激动剂包括三磷酸腺苷（ATP）、二磷酸腺苷（ADP）、三磷酸尿苷（UTP）、二磷酸尿苷（UDP），核苷酸糖和二核苷酸等。P2Y受体在机体组织内广泛表达，在免疫应答中发挥着重要作用。近年来随着研究深入，P2Y受体在炎症、癌症、心血管和神经退行性疾病中显示出作为药物靶标的巨大潜力，P2Y受体的研究对新药的进一步开发有着重要的意义。本文就P2Y受体的分类、结构，药理学特性及以P2Y受体为靶点的潜在药物等作一综述。

Advances in research on the function of purinergic receptor P2Y in immune inflammation

P2Y receptor (P2YRs) is a kind of G protein coupled receptor (GPCRs) activated by extracellular nucleotides, belonging to purine receptor family.The physiological activators of P2Y receptors include dinucleotide or triphosphate nucleotide purine and pyrimidine, such as ATP, ADP, UTP, UDP, nucleotide sugar and dinucleotide.P2Y receptor is widely expressed in tissue and plays an important role in immune response. In recent years, P2Y receptor has shown great potential as a drug target in inflammation, cancer, cardiovascular and neurodegenerative diseases, and the study of P2Y receptor is of great significance for the further development of new drugs. In this paper, the classification, structure, pharmacological properties of P2Y receptor and potential drugs targeted at P2Y receptor are reviewed.