甲状腺结节微波消融术后体温及炎性指标变化规律及其意义

目的观察微波消融(MWA)治疗甲状腺结节后患者体温及炎性指标变化,并探讨其意义。方法选取93例接受MWA治疗的甲状腺结节患者(160枚结节)。测量消融前及消融后30 min、12 h、24 h及48 h时腋下体温;于消融前及消融后24 h检测白细胞(WBC)、中性粒细胞百分比(NEU%)、红细胞沉降率(ESR)、C反应蛋白(CRP)、白细胞介素-1(IL-1)、IL-2、IL-6、IL-8及肿瘤坏死因子(TNF)水平。结果93例均一次性完全消融,消融时间60~862 s,平均(259.11±209.85)s。消融前后各时间点腋下体温总体比较差异无统计学意义(F=0.384,P=0.820)。消融后24 h,患者WBC、IL-6、IL-8、TNF均高于消融前(P均<0.05),消融前后NEU%、ESR、CRP、IL-1、IL-2差异无统计学意义(P均>0.05)。结论MWA治疗甲状腺结节可引起部分炎性因子改变,但程度较轻,术后患者体温轻微波动。

Changes and significances of body temperature and inflammatory indexes after microwave ablation of thyroid nodules

Objective To observe the changes and significances of temperature and inflammatory factors after microwave ablation (MWA) of thyroid nodules. Methods A total of 93 cases with 160 thyroid nodules treated by MWA were enrolled. Axillary temperature was recorded before and 30 min, 12 h, 24 h, 48 h after MWA. White blood cell (WBC), neutrophile percentage (NEU%), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), interleukin-1 (IL-1), IL-2, IL-6, IL-8 and tumor necrosis factor (TNF) were tested before and 24 h after MWA. Results All 93 cases underwent complete ablation at one time, with a duration of 60-862 s and average of (259.11±209.85)s. There was no significant difference of armpit temperatures before and after ablation (F=0.384, P=0.820). WBC, IL-6, IL-8 and TNF 24 h after ablation were higher than before ablation (all P<0.05), and there was no statistically significant differences in NEU%, ESR nor CRP, IL-1, IL-2 before and after ablation (all P>0.05). Conclusion MWA of thyroid nodules can lead to slight changes of some inflammatory factors, but the patient''s which cause only slight fluctuation of body temperature fluctuate slightly.