| 熊果酸纳米制剂的研究进展 |
| |
| 作者姓名： | 方敏 李家明 李宁 赵娣 陈西敬 张广钦 |
| |
| 作者单位： | 1.中国药科大学基础医学与临床药学学院临床药学研究室，江苏 南京 211198；2.中国药科大学基础医学与临床药学学院临床药物代谢动力学研究室，江苏 南京 211198,2.中国药科大学基础医学与临床药学学院临床药物代谢动力学研究室，江苏 南京 211198,3.中国药科大学国家药学实验教学示范中心，江苏 南京 211198,2.中国药科大学基础医学与临床药学学院临床药物代谢动力学研究室，江苏 南京 211198,2.中国药科大学基础医学与临床药学学院临床药物代谢动力学研究室，江苏 南京 211198,1.中国药科大学基础医学与临床药学学院临床药学研究室，江苏 南京 211198 |
| |
| 摘 要： | 熊果酸是一种具有保肝、抗炎、抗癌等多种生物活性的五环三萜类化合物，药理活性广泛。但是，较低的水溶性和生物利用度等缺陷限制了其临床应用。因此，开发新剂型以提高熊果酸的生物利用度成为熊果酸研究的重要部分。纳米载体广泛应用于改善药物水溶性，提高药效、延长药物作用时间。本文总结了国内外熊果酸纳米制剂的相关研究，包括脂质体、胶束、纳米粒、纳米悬浮液和纳米乳，为其后续研究提供必要的思路和参考。
|
| 关 键 词： | 熊果酸 纳米制剂 脂质体 胶束 纳米粒 纳米悬浮剂 纳米乳 |
Research progress on nanoformulations of ursolic acid |
| |
| Authors: | FANG Min LI Jiaming LI Ning ZHAO Di CHEN Xijing and ZHANG Guangqin |
| |
| Institution: | 1.Clinical Pharmacy Laboratory, China Pharmaceutical University, Nanjing 211198, China;2.Clinical Pharmacokinetics Laboratory, China Pharmaceutical University, Nanjing 211198, China;3.National Experimental Teaching Demonstration Center of Pharmacy, China Pharmaceutical University, Nanjing 211198, China,1.Clinical Pharmacy Laboratory, China Pharmaceutical University, Nanjing 211198, China;2.Clinical Pharmacokinetics Laboratory, China Pharmaceutical University, Nanjing 211198, China;3.National Experimental Teaching Demonstration Center of Pharmacy, China Pharmaceutical University, Nanjing 211198, China,1.Clinical Pharmacy Laboratory, China Pharmaceutical University, Nanjing 211198, China;2.Clinical Pharmacokinetics Laboratory, China Pharmaceutical University, Nanjing 211198, China;3.National Experimental Teaching Demonstration Center of Pharmacy, China Pharmaceutical University, Nanjing 211198, China,1.Clinical Pharmacy Laboratory, China Pharmaceutical University, Nanjing 211198, China;2.Clinical Pharmacokinetics Laboratory, China Pharmaceutical University, Nanjing 211198, China;3.National Experimental Teaching Demonstration Center of Pharmacy, China Pharmaceutical University, Nanjing 211198, China,1.Clinical Pharmacy Laboratory, China Pharmaceutical University, Nanjing 211198, China;2.Clinical Pharmacokinetics Laboratory, China Pharmaceutical University, Nanjing 211198, China;3.National Experimental Teaching Demonstration Center of Pharmacy, China Pharmaceutical University, Nanjing 211198, China and 1.Clinical Pharmacy Laboratory, China Pharmaceutical University, Nanjing 211198, China;2.Clinical Pharmacokinetics Laboratory, China Pharmaceutical University, Nanjing 211198, China;3.National Experimental Teaching Demonstration Center of Pharmacy, China Pharmaceutical University, Nanjing 211198, China |
| |
| Abstract: | Ursolic acid (UA) is a pentacyclic triterpenoid compound with various biological activities such as liver protection,anti-inflammatory and anti-cancer.It has a wide range of pharmacological activities.However,lower water solubility and bioavailability limit its clinical application.Therefore, the development of new dosage forms to improve the bioavailability of ursolic acid has become an important part of ursolic acid research.Nanocarriers are widely used to improve the water solubility of drugs,improve drug efficacy,and prolong drug action time.This paper summarized the related researches on ursolic acid nano-preparations from domestic and abroad,including liposomes,micelles,nanoparticles,nanosuspensions and nanoemulsions,which will provide necessary ideas and references for the future research. |
| |
| Keywords: | Ursolic acid Nanoformulations Liposomes Micelles Nanoparticles Nanosuspension Nanoemulsion |
|
| 点击此处可从《》浏览原始摘要信息 |
| 点击此处可从《》下载免费的PDF全文 |
|
