| 椴叶鼠尾草中1个新的克罗烷型二萜化合物 |
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| 引用本文： | 范敏,段宝忠,夏从龙,王双.椴叶鼠尾草中1个新的克罗烷型二萜化合物[J].中草药,2020,51(18):4610-4613. |
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| 作者姓名： | 范敏 段宝忠 夏从龙 王双 |
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| 作者单位： | 大理大学药学院, 云南 大理 671000 |
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| 基金项目： | 大理大学博士科研启动项目（KY1819212210）；大理大学中药资源与民族药创新团队（ZKLX2019318）；大理州科技计划重大项目（D2019NA03） |
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| 摘 要： | 目的研究椴叶鼠尾草Salviatiliifolia地上部分的化学成分。方法采用硅胶、ODS、SephadexLH-20、HPLC等各种现代色谱分离技术进行系统地分离纯化,根据波谱数据对化合物进行结构鉴定。结果从椴叶鼠尾草地上部分丙酮提取物中分离得到了2个化合物,分别鉴定为1-(3-呋喃基)-8-(2-酮-2,5-二氢呋喃基)-1,7,8,9-四氢萘并1,2-c]呋喃-3,6-二酮(1)和dugesin B(2)。结论化合物1为1个新的克罗烷型二萜化合物,命名为椴叶鼠尾酮A,活性测试结果表明化合物1无明显细胞毒活性。
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| 关 键 词： | 椴叶鼠尾草|克罗烷型二萜|椴叶鼠尾酮A|细胞毒活性|dugesin B |
| 收稿时间： | 2020/3/22 0:00:00 |
A new neo-clerodane diterpenoid from Salvia tiliifolia |
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| FAN Min,DUAN Bao-zhong,XIA Cong-long,WANG Shuang.A new neo-clerodane diterpenoid from Salvia tiliifolia[J].Chinese Traditional and Herbal Drugs,2020,51(18):4610-4613. |
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| Authors: | FAN Min DUAN Bao-zhong XIA Cong-long WANG Shuang |
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| Institution: | College of Pharmacy, Dali University, Dali 671000, China |
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| Abstract: | Objective To study the chemical constituents of the aerial parts of Salvia tiliifolia. Methods The compounds were isolated and purified by various modern chromatographies, and their structures were identified by spectroscopic data. Results Two compounds were isolated from the acetone extract of the aerial parts of S. tiliifolia, which were elucidated as 1-(furan-3-yl)-8-(2-oxo-2,5-dihydrofuran-3-yl)-1,7,8,9-tetrahydronaphtho1,2-c]furan-3,6-dione (1) and dugesin B (2). Conclusion Compound 1 is a new clerodane diterpene with no cytotoxicity, named as 1-keto-tilifodiolide. |
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| Keywords: | Salvia tiliifolia Vahl|neo-clerodane diterpenoid|1-keto-tilifodiolide|cytotoxicity|dugesin B |
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